Cancer therapy articles within Nature Materials

Featured

  • News & Views |

    Lymphatic vessels within and near to tumours facilitate nanoparticle transport out of tumours, with ramifications in the design and implementation of next-generation clinical cancer nanomedicines.

    • Meghan J. O’Melia
    •  & Susan N. Thomas

  • News & Views |

    A bioengineered model incorporating a synthetic extracellular matrix recapitulates the lymphoid tumour microenvironment, making it a valuable tool for drug testing and designing personalized therapies.

    • Akhilesh K. Gaharwar
    •  & Irtisha Singh

  • Perspective |

    This Perspective discusses biological barriers that have limited clinical translation of cancer nanomedicines and elaborates on new directions for the field that capitalize on a deeper understanding of the nano–bio interface.

    • Irene de Lázaro
    •  & David J. Mooney

  • News & Views |

    An elaborate DNA origami tubular nanodevice encapsulating antigens and adjuvants protects mice from cancer through tumour-specific immunomodulation.

    • Hongjun Li
    •  & Zhen Gu

  • News & Views |

    A dose threshold of one trillion nanoparticles in mice has been discovered and is shown to be crucial for overwhelming the nanoparticle uptake kinetics of liver Kupffer cells and for ensuring efficient nanoparticle delivery into solid tumours upon intravenous administration.

    • Twan Lammers

  • News & Views |

    In situ metabolic labelling and targeted modulation of dendritic cells has been achieved using a hydrogel system in combination with covalent capture of antigens and adjuvants, facilitating improved tumour-specific immune response.

    • Joshua M. Gammon
    •  & Christopher M. Jewell

  • Article |

    A DNA nanodevice vaccine has been developed and utilized to stimulate a tumour-specific cytotoxic T lymphocyte response in vivo, leading to the inhibition of tumour growth as well as prevention of metastasis.

    • Shaoli Liu
    • , Qiao Jiang
    •  & Baoquan Ding

  • Article |

    Efficient nanoparticle delivery into tumours has been a challenge in the field. It is now shown that the efficiency can be improved substantially when the dose breaches a specific threshold.

    • Ben Ouyang
    • , Wilson Poon
    •  & Warren C. W. Chan

  • Article |

    Dendritic cells concentrated in vivo within a hydrogel have been metabolically tagged with azido groups to enable tracking as well as delivery of antigens, adjuvants and cytokines, thereby facilitating targeted immunomodulation.

    • Hua Wang
    • , Miguel C. Sobral
    •  & David J. Mooney

  • Article |

    Anticancer drugs such as Taxol can affect microtubule dynamics and organization in cells. Direct visualization of the action of such drugs has shown that they can trigger local and cooperative changes in microtubule lattice and induce formation of stable microtubule regions that promote rescues.

    • Ankit Rai
    • , Tianyang Liu
    •  & Anna Akhmanova

  • Feature |

    Camille M. Le Gall, Jorieke Weiden, Loek J. Eggermont and Carl G. Figdor provide an overview of immunotherapeutics for cancer treatment that harness dendritic cells, their challenges in clinical use, and approaches employed to enhance their recruitment and activation to promote effective anti-tumour immunity.

    • Camille M. Le Gall
    • , Jorieke Weiden
    •  & Carl G. Figdor

  • Feature |

    Darrell Irvine provides an overview of the recent advances in materials science that have enabled the use of innovative natural and synthetic compounds in vaccine development capable of regulating the potency and safety of new vaccines progressing towards the clinic.

    • Darrell Irvine

  • Editorial |

    As the interaction of the immune system with the tumour microenvironment becomes increasingly understood, more evidence indicates how immunotherapy can be employed to better eliminate cancers.

  • Feature |

    Tumour heterogeneity and off-target toxicity are current challenges of cancer immunotherapy. Karine Dzhandzhugazyan, Per Guldberg and Alexei Kirkin discuss how epigenetic induction of tumour antigens in antigen-presenting cells may form the basis for multi-target therapies.

    • Karine N. Dzhandzhugazyan
    • , Per Guldberg
    •  & Alexei F. Kirkin

  • News & Views |

    A strategy to enhance antigen immunogenicity was developed by adsorption of polyethyleneimine on a mesoporous silica microrod vaccine for the presentation of tumour viruses and neoantigens, demonstrating their ability to drive anti-tumour immunity.

    • Cornelis J. M. Melief

  • News & Views |

    The fabrication of a self-sustaining source of low-energy electrons in a single-atom layer could help unravel fundamental mechanisms of radiobiological damage and lead to improved cancer therapies.

    • Léon Sanche

  • Article |

    The sustained release of both hydrophilic and hydrophobic immunomodulators for metastatic melanoma by nanoscale liposomal polymeric gels administered intratumorally or systemically is demonstrated. It is also shown that such a co-delivery approach delays tumour growth and increases the survival of tumour-bearing mice, and that its efficacy results from the activation of both innate and adaptative immune responses.

    • Jason Park
    • , Stephen H. Wrzesinski
    •  & Tarek M. Fahmy

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