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Metal ion-directed dynamic splicing of DNA through global conformational change by intramolecular complexation
Higher-order structured DNA molecules can be manipulated to carry out specific enzymatic functions. Here the authors demonstrate the metal ion-directed global conformational control of DNA structure, using intramolecular coordination chemistry to manipulate the DNAzyme activity.
- Toshihiro Ihara
- , Hiroyuki Ohura
- & Yusuke Kitamura
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| Open AccessDysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae
The molecular basis for the high toxicity of cadmium is unclear. Here, Begg et al. use the bacterium Streptococcus pneumoniaeas a model system, and show that cadmium uptake increases sensitivity to oxidative stress by reducing intracellular concentrations of manganese and zinc through different mechanisms.
- Stephanie L. Begg
- , Bart A. Eijkelkamp
- & Christopher A. McDevitt
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Article
| Open AccessTRPM7 is essential for Mg2+ homeostasis in mammals
Magnesium is an essential element of the diet and is a cofactor for many enzymes. In this study, the channel kinase TRPM7 is shown to be essential for magnesium homeostasis, and heterozygous mice lacking the kinase domain show a defect in absorption of magnesium from the diet.
- Lillia V. Ryazanova
- , Lusliany J. Rondon
- & Alexey G. Ryazanov
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Phase diagram of bismuth in the extreme quantum limit
Electrons in metals at extremely high magnetic fields show interesting quantum structures. The authors measure the angle-dependent Nernst effect with high precision and show that, for bismuth, Coulomb interactions between the electrons become important in this ultraquantum regime.
- Huan Yang
- , Benoît Fauqué
- & Kamran Behnia