Calcium articles within Nature Communications

Featured

• Perspective
  21 February 2024 | Open Access

  Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics

  Annexins are calcium-regulated membrane binding proteins with an array of cellular activities. Here, Gerke et al. describe recent research highlighting the many functions of annexins and provide a view on directions for the future.

  • Volker Gerke
  • , Felicity N. E. Gavins
  •  & Ursula Rescher

• Article
  16 June 2023 | Open Access

  Ratiometric measurement of MAM Ca²⁺ dynamics using a modified CalfluxVTN

  MAM Ca²⁺ dynamics play an important role in diverse biological processes, but directly and specifically measuring Ca²⁺ concentrations in this region is technically challenging. Here the authors report a MAM-specific BRET-based Ca²⁺ indicator called MAM-Calflux, which works as both a Ca²⁺ indicator and a structural marker due to its ratiometric nature.

  • Eunbyul Cho
  • , Youngsik Woo
  •  & Sang Ki Park

• Article
  08 March 2019 | Open Access

  A Ca²⁺-regulated deAMPylation switch in human and bacterial FIC proteins

  In many AMPylating FIC proteins a structurally conserved glutamate represses AMPylation. Here, the authors show that this glutamate supports deAMPylation in Enterococcus faecalis FIC (EfFIC), and that EfFIC switches from AMPylation to deAMPylation by binding Ca²⁺ at distinct sites.

  • Simon Veyron
  • , Giulia Oliva
  •  & Jacqueline Cherfils

• Article
  22 February 2019 | Open Access

  Sensing intracellular calcium ions using a manganese-based MRI contrast agent

  There are only few MRI-compatible calcium reporters and they are limited to measuring extracellular calcium levels. Here the authors develop and validate a cell-permeable, manganese-based paramagnetic MRI contrast agent that enables monitoring intracellular calcium signals in vivo in the rat brain.

  • Ali Barandov
  • , Benjamin B. Bartelle
  •  & Alan Jasanoff

• Article
  06 August 2018 | Open Access

  Calcium is an essential cofactor for metal efflux by the ferroportin transporter family

  Ferroportin (Fpn) is essential for mammalian iron homeostasis as it exports iron from cells into blood circulation, but the molecular mechanisms of Fpn-mediated iron transport remain obscure. Here the authors use biophysical approaches to reveal that Ca²⁺ is a required cofactor for Fpn transport activity.

  • Chandrika N. Deshpande
  • , T. Alex Ruwe
  •  & Mika Jormakka

• Article
  14 September 2015 | Open Access

  Calcium-controlled conformational choreography in the N-terminal half of adseverin

  The calcium-regulated gelsolin family of actin-binding proteins includes adseverin. Here, the authors report the X-ray crystal structure of the N-terminal portion of adseverin and use small-angle scattering and molecular dynamics simulations to examine the calcium-dependent function of this protein.

  • Sakesit Chumnarnsilpa
  • , Robert C. Robinson
  •  & Cedric Leyrat