Featured
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Review Article |
Diagnostics for SARS-CoV-2 infections
This Review highlights the progress that has been made in the development of diagnostic tools for the detection of SARS-CoV-2 in the fight against COVID-19.
- Bhavesh D. Kevadiya
- , Jatin Machhi
- & Howard E. Gendelman
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Review Article |
Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases
This Review highlights approaches used to generate somatic cell-derived organoids for modelling epithelial tissue to understand disease progression and how they are employed in preclinical drug screening.
- Masayuki Fujii
- & Toshiro Sato
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Article |
A year-long extended release nanoformulated cabotegravir prodrug
Nanoformulated long-acting cabotegravir prodrugs are shown to be capable of extending the native drug’s antiretroviral activity, biodistribution and pharmacokinetics for up to 12 months in mice and rhesus macaques.
- Tanmay A. Kulkarni
- , Aditya N. Bade
- & Howard E. Gendelman
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Article |
Long-term implant fibrosis prevention in rodents and non-human primates using crystallized drug formulations
Foreign body response can result in failure of biomaterials in vivo. Solvent-free crystals containing anti-fibrotic drugs now show the potential for long-term inhibition of fibrosis on a number of implantable devices in rodents and non-human primates.
- Shady Farah
- , Joshua C. Doloff
- & Daniel G. Anderson
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Article |
Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury
Chemiluminescent molecular renal probes have been developed and are shown to be capable of non-invasive real-time imaging of early-stage oxidative stress biomarkers of drug-induced acute kidney injury, and high renal clearance.
- Jiaguo Huang
- , Jingchao Li
- & Kanyi Pu
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Perspective |
Exploiting machine learning for end-to-end drug discovery and development
This Perspective describes the application of machine learning models in the design, synthesis and characterisation of molecules at different stages in the drug discovery and development process.
- Sean Ekins
- , Ana C. Puhl
- & Alex M. Clark
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Article |
Quantitative self-assembly prediction yields targeted nanomedicines
Molecular simulations reveal the self-assembly of small molecules into nanoparticle drug carriers. Targeting of colon and liver cancer cells by the nanoparticles via kinase inhibitors is employed in anti-tumour therapy in vivo.
- Yosi Shamay
- , Janki Shah
- & Daniel A. Heller
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News & Views |
Longer and safer gastric residence
A supramolecular polymer that is stable in the acidic environment of the stomach but dissolves in the neutral-pH environment of the intestines prolongs the safe retention of gastric devices.
- Vitaliy V. Khutoryanskiy
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Letter |
Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines
The oral delivery of small interfering RNA (siRNA) to diseased intestinal tissue is challenging because of the harsh environment created by gastrointestinal fluids and mucosa. Now, such delivery of siRNA to sites of intestinal inflammation is achieved using polythioketal nanoparticles and gene expression is successfully inhibited in the inflamed tissue.
- D. Scott Wilson
- , Guillaume Dalmasso
- & Niren Murthy
Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung