Drug delivery articles within Nature Materials

Featured

  • Editorial |

    The fundamental discoveries that enabled the development of effective mRNA vaccines against COVID-19 were awarded with this year’s Nobel Prize in Medicine.

  • Review Article |

    RNA-based therapeutics hold promise for the treatment of several diseases. This Review provides an overview of hydrogels for RNA delivery, discussing how the chemical nature and physical properties of hydrogels can be explored for tailored RNA loading and release, and highlighting the use of these materials in biomedical applications.

    • Ruibo Zhong
    • , Sepehr Talebian
    •  & Jinjun Shi

  • News & Views |

    A large-scale screening identifies an inhalable polymer nanoparticle formulation that safely and effectively delivers therapeutic mRNA molecules to the lungs of several animal species.

    • Ronnie H. Fang
    •  & Liangfang Zhang

  • Comment |

    Semi-synthetic goldilocks material design integrates the tunable characteristics of synthetic materials and the refined complexity of natural components, enabling for the progress of biomaterials across length scales. Accelerated translational success may thus be possible for more personalized and accessible products.

    • Alessondra T. Speidel
    • , Christopher L. Grigsby
    •  & Molly M. Stevens

  • News & Views |

    Lipid nanodiscs carrying a potent STING agonist penetrate deep into solid tumours compared with gold-standard liposomes and enable long-term antitumour immunotherapy.

    • Ningqiang Gong
    •  & Michael J. Mitchell

  • News & Views |

    An implantable stent inspired by kirigami has been developed and integrated with a fluidically driven soft actuator to deliver drugs to tubular organs in the body such as the gastrointestinal and respiratory tracts.

    • Alexandra Teleki
    •  & Per Artursson

  • News & Views |

    Nanoformulations of cabotegravir prodrugs have been developed to prolong the pharmacokinetics of the antiretroviral agent. They can be present in the plasma of mice and non-human primates for a year following a single injection.

    • Vicente Soriano
    • , Pablo Barreiro
    •  & Carmen de Mendoza

  • Article |

    Nanoformulated long-acting cabotegravir prodrugs are shown to be capable of extending the native drug’s antiretroviral activity, biodistribution and pharmacokinetics for up to 12 months in mice and rhesus macaques.

    • Tanmay A. Kulkarni
    • , Aditya N. Bade
    •  & Howard E. Gendelman

  • Editorial |

    A collective effort from materials scientists, life scientists and clinicians is required to systematically address fundamental questions in the mechanisms of nanoparticle delivery in order to overcome the hurdles in translating nanomedicines for tumour therapy.

  • Comment |

    New evidence suggests that the mechanism of nanoparticle entry into solid tumours may be driven by an active process. This insight paves the way for approaches to enhance the efficiency of nanomedicine delivery by harnessing active transport mechanisms, and encourage researchers to rethink how tumours are treated.

    • Subehndu Pandit
    • , Debapriya Dutta
    •  & Shuming Nie

  • News & Views |

    New evidence now suggests that the dominant mechanism of extravasation of nanoparticles into solid tumours may be through an active process of endothelial transcytosis.

    • Irene de Lázaro
    •  & David J. Mooney

  • News & Views |

    Crystallized anti-inflammatory drugs have been shown to inhibit fibrosis on the surface of a number of devices over a long-term period following implantation in rodents and non-human primates.

    • Ruud A. Bank

  • News & Views |

    An orally administered bifunctional gastrointestinal coating has been developed and shown to limit nutrient absorption through the bowel mucosa ultimately lowering blood glucose and also acting as a platform for delivery of drugs to the gastrointestinal tract.

    • Gregor Fuhrmann

  • News & Views |

    An injectable biomaterial with angiogenic and immune-modulatory properties was developed and shown to support brain tissue repair and functional recovery in a mouse model of stroke.

    • Anup Tuladhar
    •  & Molly S. Shoichet

  • Article |

    Molecular simulations reveal the self-assembly of small molecules into nanoparticle drug carriers. Targeting of colon and liver cancer cells by the nanoparticles via kinase inhibitors is employed in anti-tumour therapy in vivo.

    • Yosi Shamay
    • , Janki Shah
    •  & Daniel A. Heller

  • News & Views |

    Drug-loaded liposomes functionalized with proteins from the cell membrane of leukocytes target inflamed tissues without eliciting a substantial immune response.

    • Kenneth A. Dawson
    •  & Yan Yan

  • Article |

    The blood clearance mechanism, by the liver, of administered hard nanomaterials is reported in relation to blood flow dynamics, organ microarchitecture and cellular phenotype.

    • Kim M. Tsoi
    • , Sonya A. MacParland
    •  & Warren C. W. Chan

  • Editorial |

    Biomedical applications for graphene are attracting interest from academics and industrial partners aiming to develop next-generation medical devices and therapies.

  • Article |

    A water-resistant sunblock based on bioadhesive nanoparticles encapsulating a model ultraviolet filter at low concentrations adheres to the stratum corneum without subsequent intra-epidermal or follicular penetration.

    • Yang Deng
    • , Asiri Ediriwickrema
    •  & W. Mark Saltzman

  • News & Views |

    A supramolecular polymer that is stable in the acidic environment of the stomach but dissolves in the neutral-pH environment of the intestines prolongs the safe retention of gastric devices.

    • Vitaliy V. Khutoryanskiy

  • News & Views |

    Porous silicon nanoneedles efficiently puncture cell monolayers, delivering biomolecules into cells both in vitro and in vivo.

    • Mark R. Prausnitz

  • Article |

    Nanoparticle-based fluorescence imaging does not usually allow cell membrane-bound particles and intracellular particles to be distinguished from each other. Now, using functionalized silver nanoparticles as plasmonic probes, this distinction can be made following a rapid, non-toxic etching process that selectively removes the extracellular nanoparticles but leaves the intracellular nanoparticles unharmed.

    • Gary B. Braun
    • , Tomas Friman
    •  & Erkki Ruoslahti

  • Commentary |

    Many materials-based therapeutic systems have reached the clinic or are in clinical trials. Here we describe materials design principles and the construction of delivery vehicles, as well as their adaptation and evaluation for human use.

    • Jeffrey A. Hubbell
    •  & Robert Langer

  • Commentary |

    Cancer nanomedicines approved so far minimize toxicity, but their efficacy is often limited by physiological barriers posed by the tumour microenvironment. Here, we discuss how these barriers can be overcome through innovative nanomedicine design and through creative manipulation of the tumour microenvironment.

    • Vikash P. Chauhan
    •  & Rakesh K. Jain

  • Review Article |

    Therapeutics based on small interfering RNA (siRNA), which in principle are able to reversibly silence any gene of interest, are under development for the treatment of cancers, viral infections, hereditary disorders and many other diseases. This Review discusses the biological challenges that siRNA delivery materials aim to overcome, as well as the most clinically advanced classes of siRNA delivery systems, including cyclodextrin–polymer nanoparticles, lipid nanoparticles and siRNA conjugates.

    • Rosemary Kanasty
    • , Joseph Robert Dorkin
    •  & Daniel Anderson

  • Review Article |

    The clinical application of vaccines has expanded from infectious diseases to cancer, enhancing our vision of how the immune system can be used to prevent and treat disease. This Review highlights recent developments, clinical successes and future challenges in the design of prophylactic, therapeutic and tolerance-inducing synthetic vaccines with inspiration from the natural immune system.

    • Darrell J. Irvine
    • , Melody A. Swartz
    •  & Gregory L. Szeto

  • Review Article |

    Nanoscale materials that deliver drugs in response to specific stimuli offer enhanced control of the drugs' release profile and distribution. This Review provides a comprehensive discussion of progress during the past five years in the design of nanoscale systems that can respond to exogenous stimuli such as temperature or variations in light or magnetic-field intensities, or to endogenous stimuli such as redox gradients or changes in pH or enzyme concentration.

    • Simona Mura
    • , Julien Nicolas
    •  & Patrick Couvreur

  • Article |

    Microneedle arrays coated with a pH-sensitive releasable layer act as an intradermal delivery system for polyelectrolyte films containing bioactive molecules for DNA vaccination. The implanted films co-deliver DNA, transfection agents and adjuvants, promoting local transfection and generating immune responses that can be tuned from days to weeks.

    • Peter C. DeMuth
    • , Younjin Min
    •  & Darrell J. Irvine

  • News & Views |

    Nanoparticle-enabled, sustained delivery of soluble hydrophilic cytokines and hydrophobic inhibitors engages the innate and adaptive immune systems to fight cancer.

    • C. Jeffrey Brinker

  • Article |

    The sustained release of both hydrophilic and hydrophobic immunomodulators for metastatic melanoma by nanoscale liposomal polymeric gels administered intratumorally or systemically is demonstrated. It is also shown that such a co-delivery approach delays tumour growth and increases the survival of tumour-bearing mice, and that its efficacy results from the activation of both innate and adaptative immune responses.

    • Jason Park
    • , Stephen H. Wrzesinski
    •  & Tarek M. Fahmy

  • News & Views |

    A dendritic polymer consisting of inversely oriented lipid head groups on a polyvalent polyglycerol scaffold makes an effective reversible biomembrane adhesive that may find use as a tissue sealant and a drug-delivery vehicle.

    • Holger Frey

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