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Article
| Open AccessTemporal dynamics of the multi-omic response to endurance exercise training
Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways.
- David Amar
- , Nicole R. Gay
- & Elena Volpi
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Obituary |
Allen J. Bard obituary: electrochemist whose techniques underpin clinical diagnostics, materials discovery and more
Innovator who pioneered scanning electrochemical microscopy, bioassays and solar fuels.
- Michael Rose
- & Henry S. White
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Spotlight |
A snapshot of Lithuania’s life-sciences landscape
Nature examines the Baltic country’s research ambitions as it marks 20 years of European Union membership.
- Jacqui Thornton
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News & Views |
Resilience lessons from ancient societies are still relevant today
What lessons can we learn from the factors that govern the resilience of human populations? A large-scale analysis examining ancient societies around the world provides a detailed look at what drives sustainability.
- John Haldon
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Article |
Airway hillocks are injury-resistant reservoirs of unique plastic stem cells
In the lungs, recently identified epithelial structures known as hillocks can act as injury-resistant reservoirs of stem cells.
- Brian Lin
- , Viral S. Shah
- & Jayaraj Rajagopal
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Article |
Structural and molecular basis of choline uptake into the brain by FLVCR2
FLVCR2 is expressed in the blood–brain barrier of mouse and human, and is the major mediator of choline uptake into the brain.
- Rosemary J. Cater
- , Dibyanti Mukherjee
- & Filippo Mancia
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News |
Controversial virus-hunting scientist skewered at US COVID-origins hearing
Lawmakers interrogated Peter Daszak over his ties to China and whether his organization, EcoHealth Alliance, has been a good steward of taxpayer dollars.
- Mariana Lenharo
- & Lauren Wolf
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Article
| Open AccessSleep pressure modulates single-neuron synapse number in zebrafish
Synapses are gained during spontaneous or forced periods of wake and lost during sleep in a neuron-subtype-dependent manner in zebrafish.
- Anya Suppermpool
- , Declan G. Lyons
- & Jason Rihel
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Article |
Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1
A structural, biochemical and metabolomic analysis reveals the mechanistic basis for transport of extracellular choline and ethanolamine into cells by the human transport protein FLVCR1.
- Yeeun Son
- , Timothy C. Kenny
- & Richard K. Hite
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Article
| Open AccessGeographic variation of mutagenic exposures in kidney cancer genomes
Whole-genome sequencing of 962 clear cell renal cell carcinomas from 11 countries shows geographic variations in somatic mutation profiles, including a mutational signature of unknown cause in 70% of cases from Japan.
- Sergey Senkin
- , Sarah Moody
- & Paul Brennan
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Article |
3D genomic mapping reveals multifocality of human pancreatic precancers
Quantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.
- Alicia M. Braxton
- , Ashley L. Kiemen
- & Laura D. Wood
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Article
| Open AccessChromatin accessibility during human first-trimester neurodevelopment
A study describes chromatin accessibility and paired gene expression across the entire developing human brain during the first trimester in the context of gene regulation and neurodevelopmental disease.
- Camiel C. A. Mannens
- , Lijuan Hu
- & Sten Linnarsson
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Article |
Mitochondrial transfer mediates endothelial cell engraftment through mitophagy
Under stressful conditions, mesenchymal stromal cells transfer mitochondria to endothelial cells through tunnelling nanotubes, and artificially transplanting mitochondria into endothelial cells improves the ability of these cells to engraft and to revascularize ischaemic tissues.
- Ruei-Zeng Lin
- , Gwang-Bum Im
- & Juan M. Melero-Martin
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Article
| Open AccessFrequent disturbances enhanced the resilience of past human populations
Analysis of population decline shows that frequent disturbances enhance a population’s capacity to resist and recover from downturns and that trade-offs exist when adopting new or alternative land-use strategies.
- Philip Riris
- , Fabio Silva
- & Xiaolin Ren
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Correspondence |
Zoos should focus on animal welfare before claiming to champion conservation
- Donald Broom
- , Hsiao Mei Yeh
- & Shawn Peng
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Research Highlight |
Not just truffles: dogs can sniff out surpassingly rare native fungus
Daisy, a member of a breed used to find fungal delicacies, detected a critically endangered Australian fungus faster than a trained human could.
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News |
First fetus-to-fetus transplant demonstrated in rats
The tissue developed into functioning kidneys and produced urine.
- Smriti Mallapaty
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News Feature |
Do cutting-edge CAR-T-cell therapies cause cancer? What the data say
Regulators have identified around 30 cases of cancer linked to this blockbuster treatment. But is CAR T to blame? The hunt is on for answers.
- Cassandra Willyard
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Where I Work |
I strive to make the Great Barrier Reef more resilient to heat stress
Matthew Nitschke grows coral symbionts in a slowly warming tank to prepare reef life for climate change.
- James Mitchell Crow
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Technology Feature |
85 million cells — and counting — at your fingertips
Chan Zuckerberg CELL by GENE Discover aims to be a one-stop shop for single-cell RNA sequencing data storage, access and analysis.
- Jeffrey M. Perkel
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News |
‘ChatGPT for CRISPR’ creates new gene-editing tools
Some of the AI-designed gene editors could be more versatile than those found in nature.
- Ewen Callaway
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Research Briefing |
Elephant-nose fish ‘see’ farther by electric sensing when in groups
The elephant-nose fish senses its environment by emitting electrical pulses. A multi-pronged investigation suggests that this remarkable sensing ability is amplified in social groups by individuals ‘listening in’ on the pulses of their neighbours.
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News |
Epic blazes threaten Arctic permafrost. Can firefighters save it?
Some scientists argue that it’s time to rethink the blanket policy of letting blazes burn themselves out in northern wildernesses.
- Jeff Tollefson
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News |
Bird flu virus has been spreading among US cows for months, RNA reveals
Genomic analysis suggests that the outbreak probably began in December or January, but a shortage of data is hampering efforts to pin down the source.
- Smriti Mallapaty
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Nature Podcast |
Audio long read: Why loneliness is bad for your health
New research is revealing the mechanisms linking loneliness and conditions like dementia, depression and cardiovascular disease.
- Saima May Sidik
- & Benjamin Thompson
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News |
Could a rare mutation that causes dwarfism also slow ageing?
People with Laron syndrome have a low risk of heart disease and a number of other age-related disorders, hinting at strategies for new treatments.
- Mariana Lenharo
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Career Feature |
Want to make a difference? Try working at an environmental non-profit organization
Moving to non-profit work requires researchers to shift their mindset to focus on applied science for policymaking and conservation practice.
- Natasha Gilbert
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News |
Rat neurons repair mouse brains — and restore sense of smell
Scientists develop hybrid mice by filling in missing cells and structures in their brains with rat stem cells.
- Sara Reardon
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News Explainer |
Bird flu in US cows: is the milk supply safe?
Pasteurized milk is probably not a threat to people, but fresh milk droplets on milking equipment could be spreading the virus in a herd.
- Julian Nowogrodzki
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Outlook |
Are robots the solution to the crisis in older-person care?
Social robots that promise companionship and stimulation for older people and those with dementia are attracting investment, but some question their benefits.
- Tammy Worth
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News |
Hello puffins, goodbye belugas: changing Arctic fjord hints at our climate future
Stunning images show an ecosystem’s upheaval as it warms at an alarming pace.
- Freda Kreier
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News Explainer |
NATO is boosting AI and climate research as scientific diplomacy remains on ice
As the military alliance created to counter the Soviet Union expands, it is prioritizing studies on how climate change affects security, cyberattacks and election interference.
- Natasha Gilbert
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Article |
Structures of human γδ T cell receptor–CD3 complex
- Weizhi Xin
- , Bangdong Huang
- & Qiang Zhou
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News |
First glowing animals lit up the oceans half a billion years ago
Family tree of ‘octocorals’ pushes origin of bioluminescence back to 540 million years ago, when the first animal species developed eyes.
- Freda Kreier
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Research Highlight |
This giant extinct salmon had tusks like a warthog
Scientists initially thought that the outsized teeth were fangs, giving rise to the ‘sabre-toothed salmon’ nickname.
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News & Views |
Marsupial genomes reveal how a skin membrane for gliding evolved
A parachute-like skin membrane, the patagium, evolved independently in several marsupial species. Genomic analysis suggests that this trait came about through different changes to the regulation of the same gene.
- Darío G. Lupiáñez
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News & Views |
Tumours form without genetic mutations
Researchers find that brief and reversible inhibition of a gene-silencing mechanism leads to irreversible tumour formation in fruit flies, challenging the idea that cancer is caused only by permanent changes to DNA.
- Anne-Kathrin Classen
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News & Views |
Targeting RNA opens therapeutic avenues for Timothy syndrome
A therapeutic strategy that alters gene expression in a rare and severe neurodevelopmental condition has been tested in stem-cell-based models of the disease, and has been shown to correct genetic and cellular defects.
- Silvia Velasco
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Research Briefing |
A chemical method for selective labelling of the key amino acid tryptophan
A broadly applicable method allows selective, rapid and efficient chemical modification of the side chain of tryptophan amino acids in proteins. This platform enables systematic, proteome-wide identification of tryptophan residues, which can form a bond (called cation–π interaction) with positively charged molecules. Such interactions are key in many biochemical processes, including protein-mediated phase separation.
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Article
| Open AccessWhole-cortex in situ sequencing reveals input-dependent area identity
BARseq interrogates the expression of 104 cell-type marker genes in 10.3 million cells over nine mouse forebrain hemispheres to reveal the role of peripheral inputs on cortical area development.
- Xiaoyin Chen
- , Stephan Fischer
- & Anthony M. Zador
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News |
WHO redefines airborne transmission: what does that mean for future pandemics?
The World Health Organization was criticized for being too slow to classify COVID-19 as airborne. Will the new terminology help next time?
- Bianca Nogrady
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Article
| Open AccessSpatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo
Topobiologically complex mini-colons—which enable the faithful in vitro recapitulation of colorectal cancer tumorigenesis and its environmental determinants—offer the possibility to reduce animal use in a wide range of experimental applications.
- L. Francisco Lorenzo-Martín
- , Tania Hübscher
- & Matthias P. Lutolf
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Article
| Open AccessEmx2 underlies the development and evolution of marsupial gliding membranes
Patagia—the mammalian gliding membrane—repeatedly originated through a process of convergent genomic evolution, whereby the regulation of Emx2 was altered by distinct cis-regulatory elements in independently evolved species.
- Jorge A. Moreno
- , Olga Dudchenko
- & Ricardo Mallarino
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Article
| Open AccessPhylogenomics and the rise of the angiosperms
Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.
- Alexandre R. Zuntini
- , Tom Carruthers
- & William J. Baker
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Article
| Open AccessPGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function
Prostaglandin E2 from the tumour microenvironment impairs interleukin-2 sensing by tumour-infiltrating lymphocytes, restricting proliferative response and promoting T cell death via metabolic impairment and ferroptosis.
- Matteo Morotti
- , Alizee J. Grimm
- & George Coukos
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Arts Review |
Las Borinqueñas remembers the forgotten Puerto Rican women who tested the first pill
Clinical trials of the first oral contraceptive recalled in a bold theatre production.
- Mariana Lenharo
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World View |
Ecologists: don’t lose touch with the joy of fieldwork
Amid the data deluge provided by lab-based techniques, such as environmental-DNA analysis, true connection still comes only in the outdoors.
- Chris Mantegna
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News & Views |
Bioengineered ‘mini-colons’ shed light on cancer progression
Cells grown on a 3D scaffold have generated a ‘mini-colon’ that mimics key features of the organ. Controlled expression of cancer-associated genes in the system offers a way to examine tumour formation over space and time.
- Nicolò Riggi
- & Felipe de Sousa e Melo
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