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During oxidative DNA demethylation, Neil DNA glycosylases stimulate processing of abasic sites generated by Tdg, which excises 5-methylcytosine oxidation products generated by Tet dioxygenases, promoting restoration of unmodified cytosines via base excision repair.
Methylation of the lysine demethylase KDM1A and the recognition of this modification by the chromodomain helicase CHD1 control androgen-dependent gene transcription and TMPRSS2-ERG gene fusion, a common translocation event in prostate cancer.
Methylation of adenosine within mRNA coding regions delays tRNA accommodation during translation and thus changes translation dynamics, which might influence protein folding.
The adhesion molecule Afadin acts as a scaffold coordinating the cortical assembly of the cellular machinery that orients the mitotic spindle and drives planar cell division.
Crystal structures of human HSF1 DNA-binding domain in complex with DNA and of the coiled-coil domain from a fungal ortholog provide insight into the mode of interaction of this transcription factor with DNA.
Crystal structures of human HSF2 DNA-binding domain bound to DNA, along with biochemical and cellular analyses, offer insight into potential regulatory interactions of this transcription factor.