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High-resolution cryo-EM structures of human RNA Pol III in both apo and elongating states provide insights into an autoinhibitory mechanism controlling the transition to transcription elongation unique to the mammalian holoenzyme.
Cryo-EM structures of human Pol III in both apo- and elongating states reveal metazoan-specific differences in the regulation of transcription termination and identify mutations relevant to human disease.
A mass spectrometry–based approach is used to investigate the mechanisms by which different NUP98 fusion proteins cause leukemia, revealing that the fusion proteins share common interactors and alter the composition of nuclear condensates.
The Ebola virus (EBOV) glycoprotein transmembrane domain interacts with membrane cholesterol. This interaction is required for viral fusion and cell entry and may explain why statins suppress EBOV infection.
Engineered soluble trimeric ACE2 constructs with intact enzymatic activity and high affinity to SARS-CoV-2 spike are shown to inhibit viral infection in cellular assays.
Cryo-EM structures of nucleic acid–sensing Toll-like receptors in complex with their trafficking chaperone UNC93B1, a protein that mediates TLR compartmentalization important for self versus non-self discrimination, provide insights into their interaction.
Biochemical and biophysical analyses of eye lenses from mouse strains that develop cataract due to mutations in α-, β-, or γ-crystallin proteins reveal that the mutant protein levels are largely reduced, but other crystallin proteins, including α-crystallins, precipitate.
The SARS-CoV-2 spike ectodomain is destabilized by cold temperature storage, an effect that can be reversed by incubation at 37 °C or by stabilizing its conformation in the ‘down’ state.
Cryo-EM structures of fungal Sec61–Sec62–Sec63 complexes show how Sec63 and Sec62 work together in a hierarchical manner to activate the Sec61 channel for protein translocation into the endoplasmic reticulum.
Cytoplasmic aggregates of TDP-43 sequester specific miRNAs and subsets of proteins, causing dysregulation of mitochondrial proteins and a global mitochondrial imbalance that augments oxidative stress and may promote ALS initiation and progression.
Denaturing CLIP analyses and functional assays in mouse ESCs reveal that PRC2 interacts with nascent transcripts via specific RNA motifs to promote POL-II pausing and to control transcription elongation within non-canonical PRC2 gene targets.
Biochemical and structural characterization of the meiotic DSB core complex of budding yeast reveals molecular architecture and DNA-binding properties similar to those of ancestral Topo VI.
Acute loss of CTCF disproportionately affects the transcription of genes that display promoter-proximal CTCF binding and are dependent on long-distance enhancers.