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Hi-C analyses of engineered Bacillus subtilis strains with defined SMC loading sites and 3D polymer simulations indicate that SMC complex encounters on the same DNA are resolved via bypassing in vivo.
A series of high-resolution cryo-EM structures of substrate-engaged human p97 AAA ATPase reveal critical conformational changes of the intersubunit signaling motifs, which contribute to the spiral staircase conformation of the D1 and D2 rings of p97.
Cryo-EM structures of the heat-activated TRP channel TRPV3 in lipid nanodiscs at different temperatures reveal a conformational wave involved in the gating process.
Lipidated Atg8 affects membrane morphology via two aromatic membrane-facing residues that are important for autophagy in budding yeast and mammalian cells.
Cryo-EM structures of zebrafish TRPM5 reveal closed and Ca2+-bound open states, a unique Ca2+ binding site that modulates voltage sensitivity and the mechanism of antagonist action.
A cryo-EM structure of SARS-CoV-2 ORF3a reveals a new fold conserved in coronaviruses, and functional experiments show ion channel activity that may be important for viral infectivity.
The canonical DNA methylation maintenance enzyme Dnmt1 displays global de novo methylation activity with greater targeting towards IAP transposons, which may contribute to their stable repression during early development.
Chemical genetic dissection of the SWI/SNF–Polycomb axis in mouse stem cells identifies an unexpected role for mSWI/SNF in repression, providing mechanistic insight into the dynamic ‘tug of war’ between transcriptional activation and repression.
Cell-based, in vitro and in vivo assays reveal that Fanconi anemia factors function in a BRCA1-dependent BIR-like pathway to restart stalled replication forks and that persistent replication stress contributes to FA pathogenesis.
ELOVLs are membrane-embedded enzymes that elongate very long chain fatty acids, precursors of sphingolipids and ceramides. The first crystal structure of a human ELOVL reveals an unexpected reaction mechanism, suggesting potential approaches for inhibition in disease.
High-throughput chemical screening identifies retinoic acid signaling as a regulatory pathway of 2-cell-like cell reprogramming and early mouse development.
Structural elucidation and functional analysis of the human GMPPA–GMPPB complex reveals how GMPPA acts as a ‘sensor’ of GDP-mannose to allosterically regulate GMPPB activity.
Structural characterization of B6, a monoclonal antibody that cross-reacts with eight β-coronavirus spike proteins from three viral lineages, reveals a conserved cryptic epitope that could serve as a target for structure-guided design of a pan-β-coronavirus vaccine.