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Biochemical and genome-wide analyses reveal that G4 structures sequester and inhibit the activity of DNMT1, thereby protecting CpG islands from methylation in human cells.
Newly developed assays to isolate and sequence direct NMD decay intermediates show that these are ribosome bound and can be subject to the addition of non-templated nucleotides, which affects their decay.
Downregulation of the splicing regulator ESRP2 after liver injury activates a neonatal alternative splicing program that attenuates Hippo signaling in regenerating hepatocytes.
Cryo-EM data and functional assays reveal how the actin-cross-linking protein filamin A interacts with F-actin, rationalizing human disease mutations in molecular detail.
Cryo-EM and electrophysiological studies of two mechanosensitive OSCA channels from Arabidopsis thaliana reveal their structural similarity to osmosensitive TMEM16 channels and suggest they are gated by force from lipid in response to osmotic stress.
Structural, biochemical, and modeling studies reveal how the non-canonical RNA Pol II subunit Gdown1 precludes general transcription factor interactions with Pol II(G) to repress transcriptional activity in the absence of Mediator.
Single-molecule and biochemistry approaches are used to investigate how ultra-fine DNA bridges, which form between sister chromatids during anaphase, are recognized and processed by cellular factors PICH, BLM, TopoIIIα and RPA.
Influenza A virus (IAV) infection induces transcription termination defects in host cells, an effect modulated by SUMOylation of an intrinsically disordered region of the influenza NS1 protein expressed by the 1918 pandemic IAV strain.
X-ray crystal structures and mutational analysis of the Arp8 module of the yeast chromatin remodeler INO80 reveal its function as a linker DNA sensor required for nucleosome positioning.
Structural and biochemical analyses identify the ZZ domain of p300 as a novel histone H3–binding module that promotes p300 chromatin association and is required for selective acetylation of H3K18 and H3K27 in human cells.
The interactions between HIV-1 Env and host cell receptors CD4 and CCR5 or CXCR4 are examined using direct stochastic optical reconstruction microscopy and fluorescence fluctuation spectroscopy imaging, revealing a dynamic three-step process leading to formation of the pre-fusion complex.
Cryo-EM analyses of human LRRC8A show a homohexameric assembly that can adopt two conformations, compact or relaxed, indicating rigid-body motions that might be involved in channel gating.
A new approach to map nucleosome array regularity and spacing reveals modulation of array regularity and nucleosome repeat length depending on functional chromatin states.
Four crystal structures of the human serotonin receptor 5-HT2BR in complex with chemically and pharmacologically diverse drugs elucidate the structural bases for receptor activation, agonist-mediated biased signaling and β-arrestin2 translocation.
In situ Hi-C and other genome-wide and imaging analyses in different mouse embryonic cell types reveal that the noncanonical SMC protein Smchd1 regulates long-range chromatin interactions and the developmental silencing of Hox genes.
The cryo-electron microscopy structures of the mouse TRPV3 channel, in the closed apo and agonist-bound open conformations, provide insights into the mechanism of activation.
In vitro assays and high-resolution microscopy show that Pol II CTD undergoes length-dependent liquid phase separation and controls Pol II clustering and mobility in human cells.
A screen for C. elegans antiviral-defense genes identifies a homolog of the mammalian TUT4(7) terminal uridylyltransferase genes and leads to the discovery of 3′-terminal uridylation of viral RNAs as a conserved antiviral defense mechanism.
A set of GFP fusions with as few as 12 residues appended to the C terminus is shown to assemble into filaments in E. coli. Crystal structures reveal a mechanism termed ‘runaway domain coupling’ and illustrate how protein filament formation can evolve.