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Using integrative multiomics, a new study has shed light on the aetiology of ischaemic stroke. By probing the mechanisms underlying stroke, such approaches could aid the development of therapies and improve risk prediction and stratification, with the ultimate aim of developing personalized preventive and therapeutic strategies.
Increasing evidence suggests that inflammasome activation contributes to disease progression in a wide variety of neurological conditions. In this Review, Ravichandran and Heneka discuss current understanding of inflammasome activation in neurological disorders and consider interventional strategies that target inflammasome activation.
This Review provides a comprehensive summary of the growing number of molecular therapies for the treatment of myasthenia gravis, including monoclonal antibodies, B cell-depleting agents and chimeric antigen receptor T cell-based therapies.
Autonomic nervous system dysregulation contributes to the chronic, debilitating disorders referred to as ‘long COVID’ or post-acute sequelae of SARS-CoV-2 infection (PASC). Here, Goldstein describes a multisystem, multidisciplinary approach to understanding PASC-induced alterations in feedback-regulated, plastic networks that determine homeostasis and allostasis.
In this Perspective, Zech and Winkelmann outline multidimensional strategies for genetic diagnosis in patients with rare movement disorders and highlight community-driven data-sharing and case-matchmaking platforms designed to foster the discovery of new genotype–phenotype relationships.
