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A new study shows that interactions of the cellular prion protein with amyloid-β, tau and α-synuclein oligomers are important in mediating the toxicity of these proteins in Alzheimer disease and Parkinson disease. The findings suggest a shared pathway that could be a therapeutic target common to multiple neurodegenerative diseases.
A new study has identified an association between socioeconomic status and the risk of disability in individuals with multiple sclerosis. The findings highlight the importance of collecting large, structured datasets for the study of modifiable risk factors.
Few therapies for spinal cord injury (SCI) have successfully reached the clinic, owing to the complex nature of the injury. This Review highlights two potential new multi-target therapeutic strategies for SCI: olfactory mucosa-derived mesenchymal stromal cells and heparan sulfate mimetics.
In this Review, Wardlaw et al. discuss the anatomy, physiology and pathology of perivascular spaces, particularly as seen with MRI in humans, and consider translation from models to humans to highlight knowns, unknowns, controversies and clinical relevance.
In this Consensus statement, the Magnetic Resonance Imaging in MS (MAGNIMS) study group reviews the application of brain and spinal cord atrophy in clinical practice in the management of MS and makes consensus statements and recommendations for future research.
Neuromyelitis optica spectrum disorders (NMOSD) are a type of neurological autoimmune disease characterized by attacks of CNS inflammation. In this Review, the authors discuss the relationship between pregnancy outcomes and NMOSD disease activity, and outline potential treatment approaches.
Risk prediction scores for dementia can help clinicians to identify at-risk individuals. If appropriately validated, these scores can also help quantify prevention potential and direct individuals to the most appropriate interventions. A new study validated the CAIDE dementia risk score by associating it with biomarker change over time.
In this Review, Tolosa et al. discuss the strategies in development for disease-modifying treatments in Parkinson disease cause by mutations in the LRRK2 gene, and consider the challenges in designing and implementing clinical trials in this condition.
Degenerative cervical myelopathy is the leading cause of spinal cord dysfunction in adults worldwide. In this Review, the authors provide a comprehensive pathophysiological and clinical overview of the condition to equip physicians across broad disciplines with the knowledge needed for its diagnosis and management.
In this Review, the authors discuss the results of recent postmortem studies of essential tremor and propose a disease model that involves both primary neurodegenerative changes and compensatory responses.
Evidence suggests that chronic neuroinflammation has an important role in the pathogenesis of Alzheimer disease. However, in a new clinical trial, the tetracycline antibiotic minocycline, which has anti-inflammatory properties, failed to delay disease progression in individuals with mild Alzheimer disease.
In the first published efficacy study of cenobamate for treatment-resistant focal seizures, high doses produced high seizure-free rates, suggesting cenobamate can outperform existing options. A risk of serious rash and low tolerability at higher doses means further safety studies and clinical experience are needed to determine its clinical value.
The influence of migration on disease risk has long been an important consideration in multiple sclerosis (MS) epidemiological research. Taking advantage of recent methodological advances, including access to population-based administrative health data, a new study highlights the importance of country of origin and duration of residence in the host country in determining MS risk.
Sex-based differences in demographics, clinical features and therapeutic response are emerging in a range of neurological diseases, including movement disorders. The authors review current knowledge of sex-related differences in Parkinson disease, essential tremor, dystonia, Huntington disease and chronic tic disorders.
