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    A web focus from Cell Death & Differentiation, Cell Death & Disease, Nature Reviews Cancer, Nature Cell Biology, Nature Reviews Molecular Cell Biology and Nature Structural & Molecular Biology. We hope you enjoy this focus including work from the world's most recognized experts in the field of autophagy.

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    With human life spans continuing to increase worldwide, the ability to keep brain functions intact into old age becomes ever more important. As the articles in this Clinical Collection illustrate, approaches to preventing or arresting neurodegeneration can take many forms, from lifestyle changes aimed at preserving the integrity of the brain, to pharmacological treatments and immunological interventions targeted at specific neurodegenerative disease mechanisms.

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    Chronic pain is estimated to affect over one-quarter of the world's population, and presents a considerable therapeutic challenge. This Nature Collection brings together articles from Nature,Nature Medicine,Nature Neuroscience,Nature Reviews NeurologyandNature Reviews Neurosciencethat highlight recent advances towards understanding the risk factors and mechanisms that underlie chronic pain, and developing effective, non-addictive treatments for this highly prevalent condition.

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    Stroke is the second most common cause of death worldwide and a major source of morbidity. Stroke is strongly associated with atrial fibrillation, the most prevalent cardiac arrhythmia, and with transcatheter aortic valve therapeutics, the use of which is becoming more widespread. This collection of articles from Nature Reviews CardiologyandNature Reviews Neurologycomprises a selection of three Reviews, one Perspectives article and five News & Views, which explore advances in our understanding of the pathophysiology, assessment, prevention and management of ischemic stroke.

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    Multiple sclerosis is an inflammatory disease of the CNS characterized by demyelinating lesions and axonal damage, and is the most common cause of neurological disability among young adults. This collection brings together international experts on a range of aspects of multiple sclerosis, including genetics, imaging, epidemiology, and new approaches to treatment.