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In this Review, Caballero-Flores, Pickard and Núñez explore how the microbiota limits colonization by pathogens and the strategies used by pathogens to counter colonization resistance.
Although numerous tick-borne viruses are seemingly apathogenic in humans, a number of emerging tick-borne viruses have been recently identified to possess human-infection potential, with more yet to be discovered. Here, we call for greater research efforts to better delineate their precise disease burden and threats posed to global public health.
Arevalo et al. have developed a nucleoside-modified mRNA-lipid nanoparticle vaccine encoding separate haemagglutinin antigens from all known influenza virus subtypes.
Meyer et al. show that Toxoplasma gondii infection influences wolf behaviour in the wild, increasing risk-taking behaviours such as dispersing from a pack and becoming a pack leader.
This study reports that mycobiota-derived metabolites can feed pathogenic Salmonella enterica subsp. enterica serovar Typhimurium and promote its competitive advantage, thus revealing a role of the fungal community during bacterial infection.
In this Review, Kim and Diamond highlight recent advances in our understanding of the host factors required for alphavirus entry, the mechanisms of action by which protective antibodies inhibit different steps in the alphavirus infection cycle and candidate alphavirus vaccines currently under clinical evaluation.
Sewage surveillance could provide information on the resistance situation in the underlying population and on environmental transmission risks. There are opportunities to make such surveillance data more informative and actionable, but there are also challenges.
This study reports that Enterococcus species can remodel the metabolic environment in the gut and reprogramme the metabolism of Clostridioides difficile, enhancing its fitness and virulence.
A better understanding of the transmission of SARS-CoV-2 is essential to inform public health measures. In this Review, Puhach, Meyer and Eckerle explore insights into what influences SARS-CoV-2 shedding, how this drives transmission and the tools available to measure this and determine infectiousness.
This month’s Genome Watch highlights how genome sequencing can be used to understand the strain-level diversity, evolution and spatial structure of the human microbiome, and to inform therapeutic strategies.
This Review discusses the ecophysiology and diversity of Trichoderma and the complexity of its relationships in the agroecosystem environment. Considerations are also presented on how to advance Trichoderma applications in real-world scenarios, contributing towards eco-sustainable agriculture.
In this Review, Blair, Webber and colleagues explore our understanding of the mechanisms of antibiotic resistance, including reduced permeability, antibiotic efflux, modification or alteration of the antibiotic target, modification or destruction of the drug itself, and bypass of metabolic pathways. They also discuss how this information can aid in developing the next generation of antimicrobial therapies.
This study reports the identification of a highly divergent lineage of SARS-CoV-2 in white-tailed deer and provides evidence of deer-to-human transmission.