News & Comment

A plant complex comprising SUVH1, SUVH3, DNAJ1 and DNAJ2 counteracts DNA-methylation-mediated silencing of transposon-neighbouring genes.

Mitochondrial dynamics regulates stem cell expansion and differentiation.

STELLA protects the genome of mouse oocytes from de novo DNA methylation by the E3 ubiquitin ligase UHRF1 and the DNA methyltransferase DNMT1.

DNA N⁶-adenosine methylation is a transgenerational epigenetic modification that confers mitochondrial stress adaptation in the nematode Caenorhabditis elegans.

David Barford discusses how the template model for MAD2 activation in the spindle assembly checkpoint represented a new concept for generating and propagating intracellular signals.

The RNA-binding protein TIS11B forms a membraneless organelle, the TIS granule, in an endoplasmic reticulum (ER) subdomain termed the TIS granule–ER (TIGER) domain, which facilitates 3ʹ UTR-mediated protein–protein interactions that regulate protein trafficking.

The first demonstration of a mechanism for active sorting of anterograde cargo in the Golgi via protein palmitoylation.

Excessive microtubule polyglutamylation has been linked to neurodegeneration.

Charles Darwin’s Pangenesis theory, which proposed an intercellular mechanism for the flow of hereditary information, is gaining new ground.

Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.

Transcription elongation supported by the super elongation complex, and H3K9 methylation and gene repression by G9a mediate the oncogenic function of Myc.

Endothelial cells in white adipose tissue communicate with adipocytes through extracellular vesicles, relaying systemic metabolic information.

Adriano Aguzzi discusses the endeavours of the Gitler team to identify the causes underlying the fatal human neurological disease amyotrophic lateral sclerosis (ALS).

DNA double-strand breaks at active genes are repaired by a dedicated homologous recombination mechanism involving R-loop formation and RAD52 recruitment.

Nature Reviews Molecular Cell Biology congratulates the winners of the 2018 Lasker Foundation Awards.

The introduction of DNA-chain terminators for sequencing by Fred Sanger enabled the early genome sequencing projects.

The kinase ATR senses the completion of DNA replication and controls the S/G2 cell-cycle transition.

Direct demonstration that mutations in intrinsically disordered regions modulate protein–protein interaction networks, which may cause disease.

Dan Fletcher’s lab comments on the unique properties of membranes at cell–cell adhesions, suggesting that cell–cell interfaces are a separate cellular compartment.

3′uridylation by TUT4 and TUT7 is shown as a post-transcriptional mechanism restricting retrotransposition of LINE-1 elements and also replication of animal RNA viruses.