News & Comment

Claire Durrant reminds us of the importance of studying the physiological roles of proteins and their aggregates to understand their roles in disease and inform therapies, discussing a 2008 paper on amyloid-β from the Arancio lab.

Stephanie Moon discusses findings that revealed that ribosome stalling can lead to the suppression of translation initiation in the brain, delaying the onset of neurodegeneration.

The first evidence that the formation of protein complexes is linked to protein synthesis was already provided in the early 1960s.

In the Journal Club, Fabrizio d’Adda di Fagagna remembers how the work of Judy Campisi changed our understanding of cellular senescence and its effect on physiology and ageing, shaping the future of this research field.

Imaging of fluorescently labelled nascent RNA in live cells enabled real-time observation of transcription of an endogenous gene.

Ahna Skop and Karen Schindler describe a paper that found localized translation in mammalian embryos, demonstrating the importance of RNA transport for development.

The story of a paper that established the concept of codon optimality and its connection with translation efficiency and mRNA decay.

Joana Vidigal reminds us of the first paper to report an endogenous role of the nucleolytic activity of the mammalian RNAi protein argonaute-2.

Florian Heyd describes a paper that pointed towards alternative splicing as a driver of human cognitive abilities.

Emily Wong describes a study that provided a quantitative methodology for analyzing ChIP experiments and shifted our understanding of the functionality of transcription factors.

Ernst and Renne highlight two papers, one that discovered and another that structurally defined the ER–mitochondria encounter structure (ERMES) that facilitates the exchange of lipids between the ER and mitochondria.

Two papers published in 1991 established a new class of human genetic disorders, caused by expansion of simple DNA repeats.

The first study to show, in C. elegans, that sensory neurons have a role in lifespan regulation.

Antennapedia proteins were among the first proteins found to be exchanged intercellularly. This discovery by Alain Prochiantz and colleagues has inspired researchers of various backgrounds.

Bulut-Karslıoğlu remembers the publication of two seminal papers that described bivalent chromatin and how this discovery continues to affect research to this day.

Anne West recounts the study that showed postnatal accumulation of non-CpG DNA methylation in neurons coinciding with postnatal synapse maturation, suggesting that it contributes to brain function.

Cutler and Vijg remind us of the publication that laid the foundation for genetic mutation theories of ageing.

Diana Pinheiro recounts two seminal papers describing how cell surface tension dictates how cells sort into different tissues during development.

Zuzana Storchová recounts the discovery of the subtle yet significant consequences of polyploidy.

The discovery that peripheral organs such as the spleen support blood formation following radiation has inspired haematology research for over five decades.