News & Comment

The exonuclease EXD2 prevents the overload of the mitochondrial 28S ribosome subunit with mitochondrial mRNAs, and is important for development and lifespan regulation

Caixia Gao outlines the technical, regulatory and public opinion hurdles for the future use of CRISPR technologies in plant breeding.

AMPK phosphorylates EZH2 — the catalytic subunit of the Polycomb repressive complex 2, thereby inhibiting its gene suppression function and counteracting its tumorigenic effects.

Eva Nogales looks back at the early days of structure determination of cytoskeletal components.

Basal mitophagy can occur independently of the kinase PINK1 in mammalian organisms, calling for further studies to elucidate the mechanisms of mitophagyin vivo.

Mary Herbert and Doug Turnbull discuss how the transmission of pathogenic mutations in mitochondrial DNA may be prevented by reproductive techniques designed to replace the mitochondria in eggs from affected women.

In stress conditions the intrinsically disordered region of the prion and translation factor Sup35 promotes reversible protein phase separation instead of the more stable fibrillar aggregation.

The term 'epigenetics' has multiple interpretations, so we need to be clear which definition we are using, argues John Greally.