Expert Recommendation

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  • Senescent cells have complex and important roles in cancer and ageing, but they are quite rare and difficult to characterize in tissues in vivo. In this Expert Recommendation, the SenNet Biomarkers Working Group discusses recent advances in detecting and characterizing cellular senescence and provides recommendations for senescence markers in 14 human and mouse tissues.

    • Vidyani Suryadevara
    • Adam D. Hudgins
    • Nicola Neretti
    Expert Recommendation
  • Extracellular vesicles (EVs) mediate cell–cell communication in physiology and pathology but many questions remain about the mechanisms governing their delivery to recipient cells. This Expert Recommendation article highlights areas of progress and challenges in establishing the importance of EV-mediated communication in vivo.

    • Guillaume van Niel
    • David R. F. Carter
    • Pieter Vader
    Expert Recommendation
  • Reactive oxygen species (ROS) comprise a wide variety of oxidant molecules with vastly different properties and biological functions in physiology and in disease. Approaches to characterize oxidants in the in vivo context and identify their specific cellular targets will be required to understand and control the pathophysiological activities of ROS.

    • Helmut Sies
    • Vsevolod V. Belousov
    • Christine Winterbourn
    Expert Recommendation