Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
So-called super-antibodies are highly potent, broadly reactive antiviral antibodies that offer promise for the treatment of various chronic and emerging viruses. This Review describes how recent technological advances led to their isolation from rare, infected individuals and their development for the prevention and treatment of various viral infections.
Here, Koji Taniguchi and Michael Karin discuss the key roles of the nuclear factor-κB (NF-κB) transcription factor in cancer-related inflammation and consider the potential of targeting NF-κB in different types of cancer.
Normalization of the tumour vasculature can improve immune effector cell infiltration, leading to immunotherapy potentiation. In this Opinion article, Huanget al. propose that reciprocal regulation between tumour vascular normalization and immune reprogramming forms a positive feedback loop that can induce durable antitumour immunity within the tumour microenvironment.
Although systemic infection is a hallmark of malaria disease, less is known regarding how parasitized erythrocytes interact locally with host tissues. In this Review, the authors discuss how infected erythrocytes reach different tissue environments and cause specific pathological consequences in malaria.
Monocytes and tissue macrophages represent two main branches of the mononuclear phagocyte system, and they have complementary roles during immunological challenges. Several studies published in 2017 highlighted the distinct properties of these two cell types and furthered our understanding of their development and cellular functions.
Technological advances have given valuable insight into the molecular mechanisms that underpin the association between HLA genetics and disease. Dendrou and colleagues review mechanisms of HLA–peptide–T cell receptor binding in health and disease and discuss how this knowledge may be translated into clinical benefit.
Peptidoglycan is an important structural component of bacterial cell walls, and mammalian cells express a number of distinct pattern-recognition receptors that detect peptidoglycan fragments. Here, the authors discuss new insights into the role of peptidoglycan recognition in inflammation, metabolism and disease.
