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A systematic analysis of the ageing immune system of the mouse revealed the emergence of a novel T cell subset that displays markers of exhaustion. A similar T cell subset was also identified in ageing humans.
A recent study in Science describes that maternal allergen-specific IgE can cross the placenta to sensitize fetal mast cells in mice and predispose to neonatal allergy.
This report shows that trained immunity, a form of innate immune memory, can be induced through nanobiologics and that these have anticancer properties and can sensitize to checkpoint therapy.
Upregulation of the protease ADAMTS4 by activated fibroblasts drives immunopathology in the lungs and respiratory failure during severe viral infections.
In this Comment article, Sandy Douglas and Adrian Hill discuss the immunological considerations associated with a risk–benefit analysis for controlled human infection models of SARS-CoV-2.
The tetracycline antibiotic doxycycline is shown to not only have direct antimicrobial effects but also promote disease tolerance mechanisms, including tissue repair and metabolic reprogramming.
Neurological symptoms are increasingly being observed in patients with COVID-19; this Comment article considers whether cross-reactive antibodies might contribute to the pathology associated with SARS-CoV-2 infection.
This Web Watch introduces the VaC tracker, a web resource that features an overview of the COVID-19 ‘vaccine landscape’, a clinical trials database and a ‘living review’ that distils the results of vaccine trials as they become available.