Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Sizun Jiang (while in the Garry Nolan lab) describes a method termed PANINI that allows simultaneous detection of nucleic acids at low copy numbers and protein markers in intact tissues, offering valuable insights into virus–immune system interactions and beyond.
In this Tools of the Trade article, Giulia Adriani and Andrea Pavesi describe a new microfluidic device that supports the generation of vascularized 3D tumour models.
In this Tools of the Trade article, Zülal Cibir and Matthias Gunzer introduce their multi-lens array microscope called ComplexEye that allows high-throughput analysis of cell migration.
In this Tools of the Trade article, Leanne Arakkal (of the Ronald Germain group) describes a technique for highly multiplexed imaging of intact tissues.
In this Tools of the Trade article, Lisa Wagar (while in the Mark Davis lab) developed an in vitro immune organoid system from primary human lymphoid tissue that recapitulates productive adaptive immune responses.
In this Tools of the Trade article, Yury Goltsev and Garry Nolan describe a multiplexed tissue imaging technique called CODEX that enables rapid tissue staining with multiple DNA-barcoded antibodies.
In this Tools of the Trade article, Christa Haase (at the Charles Lin lab) describes a technique called Image-seq that enables image-guided cell isolation from a specific, intact tissue location for subsequent single-cell gene expression analysis.
In this Tools of the Trade article, Xiaoyun Dai (of the Sidi Chen lab) developed a CRISPR-based platform termed CLASH to generate a large pool of precisely gene-modified CAR T cells, from which the most desirable variants could be selected.