Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Hybrid immunity occurs in those who have been both infected with and vaccinated against SARS-CoV-2. But how well does such hybrid immunity protect against the virus and its emerging variants?
Three papers in Nature identify ZBP1 as a key effector of cell death and inflammation downstream of ADAR mutation, as occurs in patients with Aicardi-Goutières syndrome.
In the time of the COVID-19 pandemic, anti-vaccine activism in the USA accelerated, amplified and formed an alliance with political groups and even extremists. An organized, well-funded and empowered anti-science movement now threatens to spill over and threaten all childhood immunizations in the USA and globally.
Established models of behavioural science can help to explain the suboptimal COVID-19 vaccine uptake even in countries with a plentiful supply, showing that increasing vaccination is not just about increasing knowledge and motivation, but also about increasing the opportunity for vaccination.
A preprint by Buquicchio et al. looks at the chromatin landscape of memory CD8+ T cells over the course of their development during acute and chronic viral infections.
A preprint by Cheng et al. describes how differential expression of the X-chromosome-encoded epigenetic regulator UTX contributes to sex-based differences in natural killer cell frequency and function.
Vitamin D has received much interest during the COVID-19 pandemic as a potential prophylactic or therapeutic agent — but do the available data support its use?
IL-17 production by skin-resident γδ T cells is required for optimal HIF1α activation in damaged epithelium, leading to epithelial cell migration and re-epithelialization.
The non-pharmaceutical interventions that were introduced to limit the spread of SARS-CoV-2 have also affected the transmission of respiratory syncytial virus, particularly its seasonality, with implications for the deployment of new monoclonal antibodies and vaccines.
Medullary thymic epithelial cells co-opt lineage-defining transcription factors to mimic numerous peripheral cell types and express their antigens against which maturing T cells can be tolerized.
As part of our Women in Immunology series, this article pays tribute to Lydia Rabinowitsch-Kempner, who is remembered not only for her work on tuberculosis and public health but also as an advocate for women’s rights.
A newly identified pregnancy-specific deacetylation of maternal antibodies expands their ability to vertically transmit protection against intracellular infection in neonates.