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Two groups have shown that personalized, neoantigen-based tumour vaccines elicit effective T cell responses in patients with advanced melanoma, leading to favourable clinical outcomes. Combination with checkpoint blockade can be of additional benefit.
Intracellular and secreted isoforms of osteopontin differentially regulate myeloid progenitors and differentiated lymphoid cells, respectively, through pro- and anti-apoptotic effects.
Ashley Moffett describes a 1995 paper by Colonna and Samaridis that provided the stimulus to understanding the link between NK cells and pre-eclampsia.
Jonathan Sprent describes a 1968 study by Graham Mitchell and Jacques Miller that showed the requirement for T cell–B cell collaboration for antibody production.
Multiscale immune profiling strategies facilitate unprecedented insights into the subtypes and composition of immune cells in the tumour microenvironment.