News & Comment

NLRP3 functions independently of the inflammasome as a transcriptional regulator of T helper 2 cell differentiation.

CD8⁺T cell exhaustion is associated with a good outcome in autoimmune and inflammatory diseases.

Endoplasmic reticulum stress in tumour-associated dendritic cells impairs their ability to activate an antitumour T cell response.

Thymic B cells directly present self-antigen for T cell negative selection.

HBP is a pathogen-associated molecular pattern (PAMP) from Gram-negative bacteria that promotes immunity following cytosolic detection.

Lymphatic vessels have been identified in the central nervous system.

An integrated DNA-binding domain in a plant immune receptor functions as a decoy to detect pathogen effectors that target host transcription factors.

Interferon-λ and interleukin-22 act synergistically to curtail rotavirus infection of intestinal epithelial cells.

Outer membrane vesicles access intestinal macrophages in a sulfatase-dependent manner where they induce inflammation in susceptible hosts.

Interleukin-7 supports metabolic activity in memory CD8⁺T cells, and should our paradigms of memory subsets be revised?

A newly identified protein, LEM, promotes CD8⁺T cell proliferation and memory formation.

T helper 17 (T_H17) cells transdifferentiate into T regulatory type 1 (T_R1) cells and contribute to the resolution of inflammation in mice.

Tumour-associated eosinophils support CD8⁺T cell-mediated rejection through chemoattraction and vascular normalization.

A newly discovered B cell-derived peptide inhibits T cell migration during inflammatory responses.