News & Comment

FLT3L-activated classical dendritic cells (DCs) drive immune responses following subcutaneous immunization, whereas migratory skin DCs dampen them.

A new study identifies inflammatory caspases as the cytoplasmic LPS receptors that trigger non-canonical inflammasome activation.

In response to intestinal tissue damage, the alarmin interleukin-33 enhances local regulatory T cell responses.

Pulmonary epithelial cells drive rhythmic neutrophil recruitment by secreting chemokines in a clock-dependent manner.

NOD2 restricts small intestinal inflammation by controlling the overgrowth of commensal bacteria.

Eosinophils initiate T helper 2 cell responses in the small intestine by promoting dendritic cell activation.

Linear ubiquitylation of the adaptor protein ASC regulates interleukin-1β production by the NLRP3 inflammasome.

Regulatory T cells suppress effector T cells by releasing exosomes that contain microRNAs.

CD4⁺T cells detect beryllium hidden within peptide–MHC class II complexes.

Interleukin-1 confers resistance to tuberculosis through the induction of eicosanoids that antagonize type I interferons.

Memory T cells synthesize the substrates for metabolic reprogramming to fatty acid oxidation in a cell-intrinsic manner.

Porphyromonas gingivalisevades immune-mediated killing and promotes inflammation to ensure its survival and drive dysbiosis.

Intracellular infection induces type III interferon production from peroxisomes.

NLRP3 inflammasomes can act extracellularly and thereby amplify the inflammatory response.

Interferon-γ production by memory T cells drives faster and more effective innate immune cell responses.

Combining CXCR2 blockade with PD1 blockade overcomes multiple mechanisms of tumour immune evasion.

Activation of the pyrin inflammasome is induced by bacterial modification of RHO GTPases.

TFEB is an evolutionarily ancient transcription factor that regulates the host response to bacterial infections.

Interleukin-9 secreted by T helper 9 cells impairs intestinal barrier function and exacerbates ulcerative colitis.