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A preprint by Martinez-Riano et al. evaluates the dynamics of antigen retention by follicular dendritic cells (FDCs) in germinal centres, showing that immune complexes accumulate in the centre of the FDC network.
Social insects such as ants form a superorganism in which individual colony members cooperate for disease defence, much like the cells of an organism. Studying social insect colonies can help to determine common principles that unite the disease defences of organisms, superorganisms and societies.
Wattrus et al. report a role for embryonic macrophages in zebrafish in promoting the death or proliferation of haematopoietic stem cells (HSCs), which regulates HSC clonality into adulthood.
Some T cells elongate their telomeres by acquiring telomeric DNA in extracellular vesicles from antigen-presenting cells, which rescues them from senescence and supports long-term immune memory.
Diurnal rhythmicity of IgA production by intestinal plasma cells is entrained by time of feeding, with effects on composition and metabolic activity of the commensal microbiota.
A bad diet, rich in fats and sugars, not only causes low-grade chronic inflammation but also activates antigen-specific autoreactive B and T cells that promote liver damage in the setting of type 2 diabetes.
Unconventional T cells of different lineages migrate from peripheral tissues to draining lymph nodes, where they operate as a connected functional unit to shape tissue-specific responses.
Wildfires are increasing globally, with several recent catastrophic wildfires linked to climate change. Here, we consider the negative impact of the toxic contaminants arising from these fires on the immune system, with a focus on how wildfire pollution can exacerbate inflammatory diseases.