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Here, John Kelton and colleagues provide an overview of vaccine-induced immune thrombotic thrombocytopenia (VITT), a very rare complication that has been observed following vaccination with adenoviral vector-based COVID-19 vaccines.
Blind mole rats are resistant to cancer. A new study describes how activation of transposons triggers an innate immune response that eliminates premalignant cells.
Shane Crotty discusses three independent studies published in 2009 that characterized T follicular helper cells as a distinct subset of CD4+ T cells on the basis of selective expression of BCL6.
Katalin Karikó describes the discovery that replacing uridine with pseudouridine renders RNA non-immunogenic. This paved the way for developing mRNA for protein replacement therapy and, surprisingly, also for mRNA-based vaccine development.
In this Journal Club, Zitvogel and Kroemer discuss a landmark study that initiated the genetic and molecular characterization of the immune–microbiota crosstalk.
Although it was known for decades that type I interferons are crucial for antiviral immunity, it was not until the discovery of cGAS and cGAMP signalling in 2013 that we understood how cytosolic DNA induces them in infected cells, as explained by Andrea Ablasser.
Eric Vivier describes the unexpected discovery of new populations of innate-like lymphocytes and the development of the innate lymphoid cell nomenclature.
Max Cooper recalls the discovery of variable lymphocyte receptors in lampreys and hagfish and explains the significance of this for understanding how adaptive immunity evolved in vertebrates.