News & Comment

Tumour-derived lactic acid dampens the activation and cytokine production of infiltrating T cells and natural killer cells, allowing tumours to escape immune detection and promoting tumour growth.

Automated analyses of high-dimensional data can align dendritic cell subsets from different tissues and across species.

Gwendalyn Randolph describes a 1981 paper by Ross Gerrity that stimulated her career focus on the trafficking of mononuclear phagocytes.

The genome of germinal centre B cells undergoes a multilayered reorganization to coordinate transcriptional reprogramming.

Fasting metabolism has opposing roles in maintaining tissue tolerance; anorexia improves survival during bacterial infection whereas it has detrimental effects during viral infection.

There are no obvious clinical symptoms of long-term deficiency of innate lymphoid cells in humans, which suggests that their postulated functions might be redundant.

Regulatory variant of peptidoglycan recognition receptors inDrosophilaresolve immune responses according to threat level.

Interleukin-1β is activated by the group AStreptococcusprotease SpeB during infection.

The lncRNAMorrbidcontrols the lifespan of short-lived myeloid cells.

Single-cell genomic analysis of ILCs from the mouse small intestine identifies high levels of diversity that are maintained by the commensal microbiota.

Traditional farming practices in Amish communities help shape the innate immune response and protect against asthma.

Defective mitochondrial metabolism results in dysfunction CD8⁺T cells in chronic viral infections and tumours.

Autoantibodies specific for type I IFNs can protect against type 1 diabetes.

An immune profile associated with the production of broadly neutralizing antibodies is identified in HIV-1-infected individuals.

Apoptosis of infected cells induces both pathogen-specific and self-reactive T helper 17 cells.

Production of neurotrophic factors by enteric glial cells controls IL-22 production by ILC3s for barrier defence.

Interferon-γ acts on inhibitory neurons to regulate social behaviour in mice

Two studies identify bispecific antibodies that show broad and potent neutralization of HIV in mouse models.

The glycolytic enzyme hexokinase can act as an innate sensor of bacterial sugars and trigger inflammasome activation.

Macrophages adjust their mitochondrial respiratory functions in response to viable bacteria.