News & Comment

Perforin-positive dendritic cells protect against metabolic syndrome and autoimmunity.

Stimulation of naive CD4⁺T cells in glutamine-deprived conditions favours differentiation into regulatory T cells.

Ruslan Medzhitov describes a 2002 paper by Craig Thompson and colleagues that brought the concept of Warburg metabolism to lymphocytes.

John O'Shea describes a 2000 paper by Roggeet al. that was the first to compare the transcriptomes of human T_H1 cells and T_H2 cells.

Neutrophils guide CD8⁺T cells into virus-infected tissue by leaving a trail of membrane particles enriched for CXCL12.

Regulatory T cells have a non-redundant role in tissue repair that is distinct from their suppressive functions.

The epigenetic modifier TET2 is required to repress interleukin-6 gene transcription and resolve inflammation.

The transcription factor ATF7 mediates epigenetic changes that lead to innate immune memory.

The intestinal microbiota activates pathogenic T cells in a model of autoimmune uveitis.

The mucosal immune system supports intestinal commensalism in multiple ways.

Malaria infection modifies endemic Burkitt lymphomas by inducing a prolonged expansion of germinal centre B cell numbers.

The first demonstration of memory NK cells in a primate species that mount a durable antigen-specific response over a period of several years.

Jeffrey Pollard describes a 2003 study by Enzleret al. that identified the immune response against bacteria as preventing chronic inflammation-associated tumour development.

Tumour suppressor p53 promotes immune tolerance by clearing apoptotic cells and upregulating immune checkpoint molecules.

Neutrophil extracellular traps (NETs) prime macrophages for interleukin-1β production in atherosclerosis.

The intestinal microbiota restrains type 2 immune responses by inducing the development of RORγt-expressing T cells.

Allan Mowat describes a 2005 study that identified the ability of CD103⁺dendritic cells to imprint T cells with gut-homing specificity.

Interleukin-26 mediates direct antimicrobial and immunostimulatory activities of T helper 17 cells.

Male and female mice process mechanical pain using distinct neuroimmune mechanisms.

An interferon-γ-mediated immune response is dominant in severe asthma.