News & Comment

A new study of individuals deficient for the ubiquitin-like protein ISG15 demonstrates a role for this molecule in regulating the type I IFN response.

Chitinase-like proteins promote innate interleukin-17 production and neutrophilia.

Clostridium difficileinfection induces the expression of interleukin-22, which regulates the complement system to eliminate systemically translocated pathobionts.

Fucosylation of intestinal epithelial cells in response to commensal or systemic bacterial stimulation promotes disease resistance and tolerance through the metabolic support of the gut microbiota.

Distinct subsets of thymic antigen-presenting cells contribute to the generation of a diverse and self-tolerant T cell repertoire.

LOX1 activates dendritic cells and B cells to boost humoral immune responses.

Epigenetic remodelling and changes in cellular metabolism are required for memory-like responses in innate immune cells.

Recombination-activating gene (RAG) proteins determine functional specialization and cellular fitness in natural killer cells.

CD4⁺T cells in newborn babies show increased production of CXCL8, which could be important for defence against infections.

Whether neutrophils kill a pathogen by phagocytosis or NETosis is determined by pathogen size.

Activation of tissue-resident memory CD8⁺T cells leads to a state of pathogen alert that induces both innate and adaptive immune responses.

Intestinal bacteria stimulate TLR5 on B cells and macrophages to promote antibody responses to subunit vaccination.

New vaccine protects monkeys from Ebola virus.

The transcription factor BCL-6 suppresses the expression of a subset of important genes in the glycolytic pathway in transitional effector T cells.

The TAM receptors MER and AXL regulate apoptotic cell uptake in diverse immune settings.

Invariant natural killer T cells can directly limit bacterial dissemination into the joints.

Dectin 2 specifically binds the mycobacterial cell wall component mannose-capped lipoarabinomannan.