News & Comment

CXCR6 signalling allows natural killer cell persistence in the liver and memory-like responses.

Neutrophil recruitment to sites of sterile inflammation involves a hierarchical series of cues.

Mechanism for the induction of endotoxin tolerance in neonatal intestinal epithelial cells.

Children who grow up on traditional farms are protected from developing asthma and allergy. But what are the exact exposures that mediate this protective farm effect, what is the important time period in which these exposures are effective and how do these exposures affect the immune system?

A systemic acute-phase protein and crosstalk with NKT cells modulate neutrophil activity.

Activation of BATF by PD1 contributes to T cell exhaustion in HIV infection.

The anti-apoptotic protein MCL1 is crucial for germinal centre B cell responses.

Adipose tissue macrophages contribute to mopping up excess lipids during weight loss.

Biphasic MAPK signalling discriminates between safe and dangerous forms of fungi.

Inflammatory responses generate endogenous TLR2 ligands that promote angiogenesis.

Islet amyloid polypeptide (IAPP) activates the NLRP3 inflammasome for IL-1β production.

T_H17 cells form contacts with neurons in EAE, resulting in neuronal dysfunction.

Spatial and temporal regulation of TLR9 signalling determines response pathway.

IL-23-activated γδ T cells promote inflammation by suppressing T_Regcells.

CD8⁺ T_Regcells prevent autoantibody production and SLE-like disease.