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Live microorganisms can be manipulated and engineered for colorectal cancer detection and treatment through methods such as faecal microbiota transplantation, native bacteria engineering and synthetic circuit engineering. Although promising, substantial effort is required to translate these approaches for clinical use.
Fatty liver disease is one of the most common liver diseases in the Middle East and North Africa region, and globally. Unfortunately, there is a lack of awareness regarding this condition. The nomenclature changes for NAFLD (to MAFLD or MASLD) have gained considerable attention in the hepatology community. Here, we present our point of view on this ongoing change and debate.
Obesity and metabolic syndrome are two complex and multifactorial conditions. This Review provides a comprehensive overview of dietary fibres, discussing physiochemical properties, microbiota interactions and therapeutic interventions for body weight and insulin resistance regulation.
Hepatic metabolic functions are altered in metabolic diseases. This Review provides a comprehensive overview of glucose metabolism in steatotic liver disease (SLD) and obesity, describes new techniques for hepatic glucose flux assessment and discusses how SLD treatments affect glucose metabolism.
Coeliac disease is an autoinflammatory disease, with the only available treatment being a lifelong gluten-free diet. Alternative therapeutic approaches are needed. This Review explores the concept of tolerance-inducing therapies for coeliac disease, highlighting the underlying mechanisms, progress, challenges and future directions.
This Review discusses the role of the gut microbiome in the conversion of primary to secondary bile acids and critically evaluates biochemical pathways that are less well understood. Insights into how secondary bile acid derivatives influence host immune function are also described.
