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Two new studies in Science characterize a CRISPR-associated nuclease–protease system that can be leveraged as a programmable protease-based RNA sensor.
A comparative genomics study published in Nature Communications provides new insight into the genomic changes underlying the convergent evolution of sociality in spiders.
A study in Nature reports the identification of new germline variants associated with particular subtypes of clonal haematopoiesis of indeterminate potential (CHIP) and their links to different health outcomes.
A new study in Nature Methods describes a computational method named UTAG (unsupervised discovery of tissue architecture with graphs) that aims to identify and quantify higher-level tissue domains from biological images without previous knowledge.
Riccardo Marioni discusses how the publication of Horvath’s epigenetic clock has affected research into ageing, rejuvenation and epigenetic epidemiology.
Luis Saraiva recalls a 1997 paper by Krings et al., which reports the sequencing of mitochondrial Neanderthal DNA extracted from a 40,000-year-old bone, enabling the direct study of the relationship between ancient and modern humans.
In this Journal Club, Morgan Levine discusses a publication by Rose and Charlesworth that provided direct evidence of the impact of natural selection on differential ageing rates.
A new paper in Science reports that human genomes encode a large repertoire of retroviral envelope-derived proteins, with potential roles in protecting from infection by other retroviruses.
A microscopy-based pooled CRISPR screening approach described in Cell enables the cellular functions of thousands of genes to be assessed at remarkable phenotypic depth.
A new study in Science reports the refactoring of genetic codes in Escherichia coli to create a bidirectional ‘genetic firewall’ that prevents genetic transfer from or to synthetic organisms.
A new study reports Epigenomic MERFISH, an imaging method that combines CUT&Tag and MERFISH to interrogate histone marks representing cis-regulatory elements in single cells while preserving spatial information.
A new study in Cell describes how topologically associating domains (TADs) of chromosomes can restructure to resolve the regulatory conflict that arises when a new gene incorporates into an ancestral TAD.
Guojie Zhang discusses a seminal paper by Alfred H. Sturtevant, in which he concluded based on his observations in fruitflies that the mutation rate is an evolving parameter.
Jagadeesh, Dey et al. report the development of ‘sc-linker’, an open-source framework that integrates scRNA-seq and GWAS data to identify disease-associated cell types and processes.
A paper in Nature Communications describes a framework for identifying seed traits in food crops that have health-promoting effects on the gut microbiome, with implications for crop improvement approaches.
A report in Molecular Cell identifies six new triggers of target-directed miRNA degradation, which are essential for normal Drosophila melanogaster embryogenesis.
A paper in Cancer Cell reports genetic ancestry-associated differences in clinical outcomes when using tumour mutational burden as a biomarker in the context of immune checkpoint inhibitor therapy.
In this Journal Club article, María Ávila-Arcos discusses a paper on a medically relevant genetic variant that was found exclusively in Indigenous populations from the Americas. She describes how this work served as inspiration for the inclusion of more diverse populations in the 1000 Genomes Project.
