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In this paper in Nature Genetics, Atkinson et al. describe Tractor, a statistical framework and software package that enables admixed populations to be included in large-scale genomics studies.
Chew et al. report in Nature Communications that short histone H2A variants are upregulated in a wide range of cancers, indicating that they become oncohistones when aberrantly expressed.
Park and colleagues describe in Nature Medicine a ‘genome-first’ approach to associate rare predicted loss-of-function genetic variants from whole-exome sequencing data with clinical phenotypes from electronic health records.
In this study in Molecular Cell, Clarke et al. describe a system that enables multiple Cas9-mediated genome edits to be introduced into cells in a defined, sequential order.
A report in Science describes in situ genome sequencing (IGS), a method that enables genomes to be simultaneously sequenced and imaged in intact samples, including early mouse embryos. IGS will facilitate insight into the relationship between genome sequence and organization.
A study in Nature Genetics applies whole-genome sequencing to monozygotic twins, their parents, partners and offspring to identify and characterize early developmental mutations, as well as the fate of mutated cells.
A study in Nature reports that adenine base editors can correct the mutation that causes Hutchinson–Gilford progeria syndrome in a mouse model of this disease, extending lifespan.
