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Gene loss is followed by the rapid emergence of new phenotypes owing to compensatory evolution, finds a recent study using experimental evolution of budding yeast lineages.
Levo et al. used quantitative single-cell live imaging to analyse the transcriptional dynamics of fly paralogues separated by long genomic distances, to determine whether they are co-regulated.
Lillian Musila highlights a paper by Quick et al., which reported the use of portable nanopore sequencing for on-site, real-time genomic surveillance during the 2014–2016 Ebola virus epidemic.
Elizabeth Mason recalls a seminal study by Raj et al., who used single-molecule approaches to expose principles governing how genes in a network cooperate to buffer perturbation while maintaining essential cellular functions.
On the occasion of Gregor Mendel’s bicentenary, the authors reflect on the history of the terms dominant and recessive, and their current use in medical genetics.
In six new studies published in Science, the Telomere-to-Telomere (T2T) Consortium reports the assembly and initial characterization of the final, previously unresolved 8% of the human genome.
Dimple Notani highlights a 1981 paper by Banerji et al. that describes the discovery of viral enhancer elements and that continues to shape her research today.
A paper in Nature Biotechnology describes epigenetic expression inference from cfDNA-sequencing (EPIC-seq), and demonstrates its use for non-invasive classification of cancers.
A paper in Molecular Cell reports EpiDamID, a new tool for simultaneously profiling transcription and histone post-translation modifications in single cells.
A recent study in Cell describes a developmentally important liquid-to-solid phase transition involving oskar ribonucleoprotein granules in Drosophila melanogaster oocytes.
In this Journal Club, Ambroise Wonkam describes how whole-exome sequencing of genetically diverse populations of African ancestry can provide insights into both complex and Mendelian disease.
In this Journal Club, Yukinori Okada recalls a 1987 publication that introduced a simple conceptual framework, the shared epitope hypothesis, to explain the genetic risk of rheumatoid arthritis conferred by HLA-DRB1 alleles.
In this Journal Club article, Geoff Faulkner discusses how a ground-breaking study of LINE-1 mobility in human genomes demonstrated not just a role in disease but also molecular details of the mechanisms of retrotransposition.
A new study in Science uses massively parallel reporter assays to show that human genetic associations are often driven by multiple genetic variants acting together within an associated locus.
In this Journal Club article, Yana Bromberg discusses an early application of machine learning for protein structure prediction — a paper that shaped her career. It illustrates the value of ensuring that machine learning approaches are rooted in known biological principles.
A paper in Science describes a system in synthetic yeast chromosomes in which the properties of genetic sequences change depending on the neighbouring transcriptional activity.
A recent paper in Nature describes how CRISPR-based engineering of wheat confers robust resistance to powdery mildew disease without negatively impacting crop growth and yields.
