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Park and colleagues describe in Nature Medicine a ‘genome-first’ approach to associate rare predicted loss-of-function genetic variants from whole-exome sequencing data with clinical phenotypes from electronic health records.
In this study in Molecular Cell, Clarke et al. describe a system that enables multiple Cas9-mediated genome edits to be introduced into cells in a defined, sequential order.
An article in Cell describes a multi-omic analysis of health risks from spaceflights that implicates mitochondrial stress and dysregulation as key drivers.
A study in Genome Biology uses EpiGo-KRAB to analyse the roles of H3K9me3 in genome organization and transcriptional repression and reveals the two functions may be distinct.
Jin et al. describe a barcoding approach for analysing metastasis, which they used to generate an organ-specific metastasis map for 500 cancer cell lines.
A study in Nature Biotechnology presents a library of transcription factors that are able to induce differentiation of human induced pluripotent stem cells as a resource for cell and tissue engineering.