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    Disorders of sex development (DSDs) are congenital conditions characterized by atypical development of chromosomal, gonadal or anatomical sex. New technologies are rapidly generating vast amounts of new data on the pathogenesis of DSDs. However, the diagnosis and management of patients with DSDs remains challenging. This Nature Reviews Endocrinology collection on DSDs includes articles from leading experts in the field, covering topics from pathogenesis and management to the transition from paediatric care to adult care.

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    Obesity is a major public health problem for which there are few approved medical therapies. Considerable interest exists in the outcome of new drug trials, understanding the mechanisms of obesity and the search for new potential therapeutic targets. Bariatric surgery is a popular obesity therapy and several procedures exist, including gastric bypass, gastric banding and sleeve gastrectomy. Additional approaches, such as adipose tissue transplantation and stem-cell therapy, have also been explored. This article collection from Nature Reviews EndocrinologyandNature Reviews Gastroenterology & Hepatologyprovides a comprehensive overview of the plethora of current and future approaches to treating obesity.

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    Type 2 diabetes mellitus is a global epidemic. Patients with this chronic disease—which they typically have for 20–40 years—have an increased risk of cardiovascular events. During the past few years, advances in drug development and the completion of several large-scale, randomized controlled trials have helped to provide strategies to reduce the risk of cardiovascular events in this group of patients. This collection of articles from Nature Reviews CardiologyandNature Reviews Endocrinologyprovides a state-of-the-art overview of current management strategies to reduce the risk of cardiovascular events in patients with type 2 diabetes mellitus and will be a welcome resource to researchers and clinicians alike.

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    Hypertension is a major, worldwide health problem owing to its high prevalence and association with increased morbidity and mortality. This collection of articles from Nature Reviews Cardiology,Nature Reviews NephrologyandNature Reviews Endocrinologycomprises a selection of 11 Reviews that discuss advances in our understanding of the mechanisms of hypertension and of the assessment, management and consequences of prehypertension and hypertension, as well as future directions for prevention and treatment.

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    This Collection of articles from Nature Reviews EndocrinologyandNature Reviews Rheumatologycovers the interesting developments within the field of osteoporosis research and includes articles on the clinical assessment of patients with osteoporosis, approaches for the prevention and management of this disease, as well as the impact of osteoporosis on health and economics worldwide.