Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Functional connectivity in the limbic system of the brain, which controls emotion and the autonomic system, is reduced in patients with Takotsubo syndrome compared with healthy individuals.
A novel bioelectronic system that combines automated arrhythmia detection with optogenetic engineering for arrhythmia termination is able to stop atrial fibrillation without the need of electrical shock in a closed-chest experimental model.
Singlet molecular oxygen generated by endothelial indoleamine 2,3-dioxygenase 1 has an important pathophysiological role in mammals in the redox regulation of arterial relaxation and blood pressure during inflammatory conditions through the formation of a tryptophan-derived metabolite
Fragmented sleep interferes with a novel neuroimmune axis involving hypocretin produced in the hypothalamus, leading to increased haematopoiesis and larger atherosclerotic lesions.
New research shows that IL-1α and IL-1β have differential effects on atherosclerosis, which is important to consider when selecting anti-inflammatory therapies for patients with cardiovascular disease.
A subset of T cells present in the small intestine modulate systemic metabolism and contribute to cardiovascular disease by limiting the bioavailability of the incretin hormone GLP1.
Statin therapy significantly reduces major vascular events irrespective of age, but less direct evidence is available on the benefit of statins for the primary prevention of cardiovascular disease in people aged >75 years, according to a meta-analysis by the Cholesterol Treatment Trialists' Collaboration.
Mutations in MYBPC3 cause increased cardiac contractility, reduced relaxation and excessive energy consumption characteristic of hypertrophic cardiomyopathy by disrupting normal myosin conformations. These abnormalities can be corrected by pharmacological targeting of myosin function.
Mobilization of regulatory T cells to the site of myocardial infarction can be promoted with the use of a CXCR4 blocker, and the regulatory T cells attenuate inflammatory gene expression in monocytes and macrophages and augment infarct repair.
LDL cholesterol is an important contributor to the risk of coronary heart disease, and its measurement is central to evaluating the effects of lipid-modifying therapies. Several ‘LDL-cholesterol’ assays exist but their methodologies differ, leading to between-assay heterogeneity in values of ‘LDL cholesterol’. We advocate the need for awareness of the potential implications.