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Predicting cancer occurrence is a difficult task. However, if predictions are accurate, they can be useful to health planners trying to optimize resources, and to assess the impact of planned interventions. How are predictions made and what are the challenges?
Krüppel-like factors are transcriptional regulators that function both as tumour suppressors and oncogenes through their control of p21 expression. This might be an important nodal point of cell control for other factors that have opposing functions in cancer.
In the 25 years since Doll and Peto published their groundbreaking report on the causes of cancers and strategies for prevention, there have been many additional epidemiological studies of cancer incidence. What do we now know about opportunities for cancer prevention?