News & Comment

Phospholipase D1 signalling may promote both tumour angiogenesis and metastasis through integrin-dependent pathways.

The activation of YAP is linked to the PI3K–mTOR regulation of cell size (growth) through the regulation of PTEN by the miR-29 family of microRNAs.

Two new studies published inCancer Cellcharacterize a context-dependent tumour suppressive role for the interleukin-like inflammatory protein TSLP.

Jenkins and colleagues identify a non-inflammatory role of TLR2 in gastric tumorigenesis.

Tavazoie and colleagues show that three microRNAs target apolipoprotein E, which is a suppressor of melanoma metastasis.

Editing of a microRNA (miRNA) is impaired in gliomas, and the non-edited and edited miRNAs have different gene targets, which promote and suppress invasive activity, respectively.

Inder Verma and colleagues provide evidence that, at least in mice, mature neurons and astrocytes can be transformed and can dedifferentiate to form gliomas.

A recent publication inNature Cell Biology indicates that the transcription factor ELF5 suppresses epithelial to mesenchymal transition and metastasis through repression of SNAI2.

A new study suggests that people with red hair and fair skin are at risk from developing melanoma because of a particular pigment in their skin.

A new study finds that metabolism might converge with epigenetic gene regulation to explain the context-dependent effects of the metabolite butyrate on colon cell proliferation.

Two groups have reported the discovery of small-molecule inhibitors of EZH2 that have the ability to selectively kill lymphoma cells with EZH2-activating mutations.

Three groups have used human trisomy 21 fetal liver cells or human trisomy 21 induced pluripotent stem cells (iPSCs) to examine the effects of trisomy 21 on the early stages of haematopoiesis.

Two prospective studies reported inThe Lancet Oncologyhave shown that mRNA expression signatures from whole blood can be used to stratify patients with castration-resistant prostate cancer into high- and low-risk groups.

New research suggests that magnetic nanoparticles could be used to induce apoptosis in cancer cells.