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The amplification of misfolded alpha-synuclein aggregates in vitro can be used for the detection, via fluorescent dyes, of pathologic amyloids in cerebrospinal fluid samples from patients affected by Parkinson’s disease, dementia with Lewy bodies or multiple-system atrophy.
This protocol describes how to use NetColoc, a freely available tool for evaluating the extent to which two related diseases, each characterized by a set of mapped genes, are colocalized in a reference gene interaction network.
A protocol for quantitative genome-wide detection of replication initiation, fork progression and termination, based on purification and strand-specific sequencing of Okazaki fragments isolated from mammalian or yeast cells.
Making microfluidic chips using 3D printers allows rapid fabrication of ready-to-use products from digital 3D designs with minimal human intervention. This ‘print–pause–print’ protocol describes how to make transparent, multimaterial chips.
This protocol combines shell-isolated nanoparticle-enhanced Raman spectroscopy and ab initio molecular dynamics simulations to unravel the directional molecular features of interfacial water, enabling a better understanding of electrocatalysis.
A surgical procedure that preserves hearing while creating an imaging window in the mouse cochlea, enabling the functional imaging of cochlear cells in vivo.
This protocol describes an in vitro vesicle formation system to reconstitute, purify and characterize plant-derived coat protein complex II vesicles from Arabidopsis thaliana suspension-cultured cells.