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Nowak-Sliwinska et al. describe a protocol for optimizing drug combinations using Feedback System Control (FSC). Drug combinations are tested in a cell-based assay in which results are entered into the FSC pipeline to predict new combinations to be tested in vitro.
Nanocomposites are particles comprising multiple components. Those prepared in this protocol—made up of MRI agents or smart drugs—are wrapped in polymers (e.g., PEG or dextran) derivatized with hydrophobic, fluorescent pyrenyl groups.
Understanding the mechanism of amyloid formation (protein aggregation) is important for developing treatments for many neurodegenerative diseases. Amylofit is a program for determining mechanisms and rates from protein aggregation kinetics.
This single nucleus-targeted sequencing approach incorporates multiplexing and targeted capture for efficient high-throughput detection of genome variants. The protocol will be particularly useful for studying rare cells and complex cell populations.