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The identity of a nanoparticle in a living system can be affected by the protein coat, or corona, that forms on its surface when it is exposed to a biological fluid. Using label-free snapshot proteomics, Stefan Tenzer, Dominic Docter, Roland Stauber and colleagues have profiled the rapid evolution of protein corona formation on silica and polystyrene nanoparticles and investigated its influence on the nanoparticle/biological interface. The cover illustrates a clustering analysis of the relative abundance of proteins from a blood plasma sample bound to silica nanoparticles.
Research data comes in various forms and levels of significance. Finding the best way to share all of the results of a research project can be difficult, but new ways are constantly emerging.
Negative and null results are routinely produced across all scientific disciplines, but rarely get reported. The key to combat the biases arising from this mismatch lies in disseminating all details about a work, rather than just positive results.
By using lanthanide-doped upconversion nanoparticles, fibre-optic sensors can display sensitivities several orders of magnitude greater than those of existing fluorescent techniques.
DNA molecules can be programmed to execute any dynamic process of chemical kinetics and can implement an algorithm for achieving consensus between multiple agents.
A theoretical study proposes the use of molecular magnets in a type of transistor in which the flow of collective spin excitations transports and processes information.
This Review examines recent advances in the use of micro- and nanoscale devices for studying epigenetic modifications, including covalent DNA modifications, differences in histone proteins and higher-order chromatin structures.
Bright luminescence from upconversion nanocrystals can be achieved by combining high-excitation irradiance with a high activator concentration. The enhanced brightness allows a single nanocrystal to be tracked, which can be used in bioimaging applications, for example.
Circulating tumour cells from patients with early-stage cancers have now been captured and characterized by using functionalized graphene oxide nanosheets.
Micromagnetic simulations describe both the current-induced motion of skyrmions in nanostripes and the nucleation of single skyrmions by spin-polarized currents.
Single-walled carbon nanotubes can target tumours in a two-step approach in which nanotubes modified with morpholino oligonucleotide sequences bind to cancer cells that have been pre-targeted with antibodies modified with oligonucleotide strands complementary to those on the nanotubes.
Quantitative label-free snapshot proteomics can be used to obtain time-resolved profiles of human plasma corona formed on silica and polystyrene nanoparticles, and shows that rapid corona formation affects early nanoparticle pathophysiology.