Volume 15 Issue 6, June 2020

Combining single-molecule localization microscopy with flow cytometry and three-dimensional localization enables the high throughput and precise localization of fluorescent molecules in live flowing cells.

Vibration modes of a single bacterium are detected experimentally by an optomechanical microcavity, providing a new method for vibrational spectrometry.

Chemical bond selection tunes the topological class of one-dimensional polymers towards organic metals.

Increased delivery to immune cells in the cortex and paracortex of the lymph node can be achieved by conjugating cargo to nanoparticles via linkers that release at programmable rates.

Membranes with subnanometre pores have the potential to provide solute-to-solute selectivity. This Perspective explores challenges and provides guidelines for designing next-generation single-species selective membranes

Polymers commonly are semiconducting or insulating because of a sizable energy gap in the density of states around the Fermi level. Yet, the phase transition from topologically trivial to non-trivial in on-surface synthesized π-conjugated polymers, due to a change of resonant form, stabilizes narrow bandgaps and bears in-gap zero-energy edge states in the non-trivial phase.

Experimental realizations of magnetic skyrmions, particle-like spin swirls with topological protection, so far have required inversion symmetry breaking or a geometrically frustrated lattice. In centrosymmetric GdRu₂Si₂, in which a geometrically frustrated lattice is absent, a skyrmion lattice phase emerges, which is probably stabilized by four-spin interactions mediated by itinerant electrons in the presence of easy-axis anisotropy.

Magneto-optical interaction of light with magnetic metasurfaces can give rise to the photonic spin Hall effect such that the light trajectory depends on the polarization of the light. For disordered systems, the probability distribution of the spin-dependent trajectories is a sensitive tool to detect random nanoscale variations in the metasurface.

A new method to form Bose–Einstein condensates of quasiparticles based on the rapid decrease in the phonon temperature was proposed and shown experimentally.

Poly(methyl methacrylate) nanocomposites embedding CsPbBr₃ perovskite nanocrystals can be used to simultaneously achieve optimized parameters in scintillator devices.

The vibration frequencies of a whole single bacterium can be measured experimentally using an optomechanical disk resonator.

Sufficiently small antimony nanoparticles form uniform voids that are reversibly filled and vacated during cycling.

A distance-dependent two-way magnetic resonance tuning platform combined with dual-contrast enhanced subtraction imaging enables quantitative sensing and imaging in deep tissues with minimal background noise.

Nanoparticles that access lymphatic vessels and are functionalized with degradable linkers, whose half-lives can be programmed, enable the controlled release of therapeutic cargo in different regions of the lymph nodes, allowing the targeting of otherwise difficult-to-reach lymphocyte subpopulations.

A high-throughput nanoscale 3D microscopy technique, combining imaging flow cytometry with a point-spread function, allows 3D localization measurements in live flowing cells.