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Volume 15 Issue 2, February 2020

Nanotherapy boosts atherosclerotic plaque clearance

In healthy tissue, dead cells are usually rapidly cleared by macrophages to ensure tissue homeostasis. However, in atherosclerosis, phagocytic clearance is impaired, and thus, large necrotic cores are formed. Flores et al. report a nanotherapy that restores the phagocytic capacity of macrophages and promotes inflammation resolution in atherosclerosis. Single-walled carbon nanotubes are first loaded with a chemical inhibitor of a key anti-phagocytic signalling pathway. Upon injection, they accumulate in macrophages within atherosclerotic plaques and reactivate phagocytosis. This Trojan horse strategy shows efficient plaque reduction in a mouse model of atherosclerosis.

Article by Leeper et al N&Vs by Fredman

IMAGE: Ryoko Hamaguchi, Harvard Medical School COVER DESIGN: Bethany Vukomanovic

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