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In healthy tissue, dead cells are usually rapidly cleared by macrophages to ensure tissue homeostasis. However, in atherosclerosis, phagocytic clearance is impaired, and thus, large necrotic cores are formed. Flores et al. report a nanotherapy that restores the phagocytic capacity of macrophages and promotes inflammation resolution in atherosclerosis. Single-walled carbon nanotubes are first loaded with a chemical inhibitor of a key anti-phagocytic signalling pathway. Upon injection, they accumulate in macrophages within atherosclerotic plaques and reactivate phagocytosis. This Trojan horse strategy shows efficient plaque reduction in a mouse model of atherosclerosis.
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A membrane placed below the plane of an emitter and a receiver can interact with the radiative modes and modulate heat transfer by as much as a factor of five.
The sensitivity and visual acuity of the eye of the shrimp L. vannamei are achieved via an exquisitely optimized nanostructured tapetum leading to a very high reflectivity in an ultrathin layer. Understanding the properties of such natural nanostructures can lead to the design of artificial photonic materials with enhanced properties.
Nanoscale heat currents between a hot and a cold surface can be modulated by as much as five times using a third element that interacts evanescently with the guided modes of the hot surface.
Tip-enhanced Raman spectroscopy can provide chemical sensitivity at a single-molecule level. Measurements on individual molecules adsorbed on a thin salt layer unveil that components of the electric field perpendicular to the tip provide sensitivity to the symmetry of the vibrational modes of the molecule.
Fast all-electrical switching of magnetic tunnel junctions is required to improve the next generation of non-volatile memory. The combination of spin–orbit torques, spin-transfer torques, and the voltage control of magnetic anisotropy permits switching latency smaller than 0.2 ns as unveiled by real-time observation of the switching dynamics.
The low carrier mobilities of TMDCs pose a challenge for applications in high-speed photodetection. Integrating vertical two-dimensional heterostructures with photonic waveguides allows the intrinsic speed limitations to be overcome and record-high photodetection bandwidths to be achieved.
Non-intrusive integration of metasurfaces with vertical cavity surface-emitting lasers enables fully arbitrary wavefront control for directional laser emission.
HER2-targeting peptide-based micelles transform into nanofibrils on binding to HER2 on cancer cells, triggering cancer cell apoptosis and tumour death in vivo.
Single-walled carbon nanotubes can restore phagocytotic properties of macrophages in artherosclerotic plaques to promote plaque clearance and combat artherosclerosis.