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Stacking graphene in the rhombohedral order to the tetralayer yields stronger Coulomb interactions, which results in insulating and metallic states with spontaneous symmetry breaking in spin, valley and layer degrees of freedom.
Nebulized mRNA delivery has broad therapeutic potential but has proven challenging. Here, the authors report on a modified lipid nanoparticle with improved conditions to allow nebulization and demonstrate its application for delivering mRNA to the lungs.
Catalytic metals dissolved in a liquid gallium solvent remain atomically dispersed. Alignments among the liquid atoms and reactants facilitate selective propylene synthesis from various hydrocarbon feedstocks.
Here the authors show that the trophi or jaws of the chitinous masticatory apparatus of marine and freshwater zooplankton rotifers can grind microplastics, independent of polymer composition, and generate particulate nanoplastics, which may accelerate the nanoplastic flux in global surface waters.
Synthetic nanoparticles coated with cell membranes show immune evasion and circulate longer. Here, a genetically engineered cell membrane expressing a SpyCatcher anchor is used as a modular nanotherapeutic drug delivery platform for high-affinity targeting and suppression of ovarian cancer.
Rheumatoid arthritis involves both inflammation and immune dysfunction, yet most therapies only target one aspect. Here, the authors report on ceria nanoparticle vesicle hybrids producing anti-inflammatory action and immunomodulation to relieve symptoms and restore normal function.
A nanoscale DNA origami turbine is shown to perform mechanical rotation by directly harvesting transmembrane potential energy from an ion-concentration gradient across a solid-state nanopore. The direction of rotation is set by the designed chiral twist in the turbine’s blades.
A major limiting factor for nonlinear efficiencies in lithium niobate waveguides, nanoscale thickness inhomogeneity, has been tackled using a fabrication approach called adapted poling.
An autonomous DNA-origami nanomachine powered by the chemical energy of DNA-templated RNA-transcription-consuming nucleoside triphosphates as fuel performs rhythmic pulsations is demonstrated. In combination with a passive follower, the nanomachine acts as a mechanical driver with molecular precision.
Nanoindentation of the microscale honeybee comb reveals a stiffness gradient that spans two orders of magnitude, which amplifies the catapult effect and facilitates solid particle repellency. By leveraging this, the study presents the fabrication of scaled-up, bioinspired stiffness-gradient elastomeric catapult-like soft actuators.
DNA-origami-based insulin assembly into well-defined nanoclusters reveals that insulin valency and spatial organization modulate insulin receptor activation and downstream responses independent of ligand concentration.
Solution-processable CdS ‘bulk’ nanocrystals show efficient on-chip lasing under quasi-continuous-wave conditions with excellent beam quality and pump thresholds.
Activation of the complement system by nanoparticles limits nanomedicine. The co-administration of fused complement inhibitors could largely block complement opsonization and unwanted granulocyte/monocyte uptake, as well as reducing side-effects of bolus-injected nanoparticles.
Bacterial protein dynamin A is shown to self-assemble at the membrane neck of dumbbell-shaped liposomes, triggering membrane hemi-scission and full scission, establishing dynamin-based single protein as a minimal synthetic divisome for synthetic cells.
An integrated transducer based on a planar superconducting resonator coupled to a silicon photonic cavity through a mechanical oscillator made from lithium niobate achieves a transduction efficiency of 0.9%.
Pentalayer graphene in the rhombohedral stacking order exhibits rich phases including a correlated insulator, isospin-polarized metals and Chern insulators. These findings demonstrate electron-correlated and topological states in crystalline 2D materials without the need for a moiré superlattice.
A reagentless, wireless, wearable aptamer nanobiosensor interfaced with a gold nanoparticle-MXene-based electrode enables the selective, automatic and non-invasive analysis of the female hormone oestradiol in sweat during menstrual cycles with subpicomolar sensitivity.
This study establishes a method for multiplexed detection of up to 40 different biomarkers in a single assay by combining nanopore sequencing with analyte-selective barcoded probes, including cardiac disease-associated microRNA directly from blood serum.