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An autonomous DNA-origami nanomachine powered by the chemical energy of DNA-templated RNA-transcription-consuming nucleoside triphosphates as fuel performs rhythmic pulsations is demonstrated. In combination with a passive follower, the nanomachine acts as a mechanical driver with molecular precision.
Nanoindentation of the microscale honeybee comb reveals a stiffness gradient that spans two orders of magnitude, which amplifies the catapult effect and facilitates solid particle repellency. By leveraging this, the study presents the fabrication of scaled-up, bioinspired stiffness-gradient elastomeric catapult-like soft actuators.
DNA-origami-based insulin assembly into well-defined nanoclusters reveals that insulin valency and spatial organization modulate insulin receptor activation and downstream responses independent of ligand concentration.
Solution-processable CdS ‘bulk’ nanocrystals show efficient on-chip lasing under quasi-continuous-wave conditions with excellent beam quality and pump thresholds.
Activation of the complement system by nanoparticles limits nanomedicine. The co-administration of fused complement inhibitors could largely block complement opsonization and unwanted granulocyte/monocyte uptake, as well as reducing side-effects of bolus-injected nanoparticles.
Bacterial protein dynamin A is shown to self-assemble at the membrane neck of dumbbell-shaped liposomes, triggering membrane hemi-scission and full scission, establishing dynamin-based single protein as a minimal synthetic divisome for synthetic cells.
An integrated transducer based on a planar superconducting resonator coupled to a silicon photonic cavity through a mechanical oscillator made from lithium niobate achieves a transduction efficiency of 0.9%.
Pentalayer graphene in the rhombohedral stacking order exhibits rich phases including a correlated insulator, isospin-polarized metals and Chern insulators. These findings demonstrate electron-correlated and topological states in crystalline 2D materials without the need for a moiré superlattice.
A reagentless, wireless, wearable aptamer nanobiosensor interfaced with a gold nanoparticle-MXene-based electrode enables the selective, automatic and non-invasive analysis of the female hormone oestradiol in sweat during menstrual cycles with subpicomolar sensitivity.
This study establishes a method for multiplexed detection of up to 40 different biomarkers in a single assay by combining nanopore sequencing with analyte-selective barcoded probes, including cardiac disease-associated microRNA directly from blood serum.
Biosynthesis of magnetosomes is of interest for a range of applications. Here, factors needed for magnetosome biosynthesis are evaluated and new diverse bacteria are engineered to biofabricate magnetic nanoparticles, facilitating translation to biotechnology and nanomedicine.
Here, the authors find a decrease in hepatic phagocytic uptake of nanoparticles in old mice due to age-associated downregulation of the scavenger receptor MARCO, which led to improved tumour delivery and antitumour efficacy of cancer nanomedicine, showing the need to consider age as a factor in therapeutics.
Nanoparticle penetration into tumours is an obstacle to cancer therapeutics. Here the authors show that the tumour vascular basement membrane constitutes a barrier that reduces nanoparticle delivery and demonstrate an immune-driven strategy to overcome the barrier, increasing nanoparticle movement into tumours.
Quantum biological electron transfer has potential in diagnostic and therapeutic settings. Here the authors report the triggered apoptosis of cancer cells using electricical input to wirelessly induce redox interactions at bio-nanoantennae in proximity to cancer cells.
Non-invasive monitoring of oxygen levels has implications in a wide range of applications. Here, the authors report that biological imaging beyond 1,500 nm enables in vivo quantitative assessment of oxyhaemoglobin saturation at vascular resolution with high sensitivity.
A transfer approach for monolayer MoS2 using polypropylene carbonate shows a negligible residue coverage of ~0.08% and an ultralow Ohmic contact resistance of ~78 Ω µm, with an excellent on/off ratio of ~1011 at 15 K.
We developed a technique to fabricate atomically precise quantum antidots with unprecedented robustness and tunable quantum hole states through self-assembled single vacancies in a two-dimensional transition metal dichalcogenide.