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The Food and Drug Administration (FDA)-approved iron supplement ferumoxytol, which contains iron oxide nanoparticles, can suppress growth of early mammary cancers and lung cancer metastasis by inducing pro-inflammatory M1 type macrophage polarization in the tumour tissue, offering a new ‘off label’ application for an approved drug.
The precise characterization of magnetic fields with a bandwidth of up to 3 GHz and localized on a nanometric scale is achieved by means of the coherent control of single electron and nuclear spins.
Pair correlation microscopy is used to show that the shape of a nanoparticle can affect the way it crosses various barriers inside a cell, and this ultimately determines the site at which the nanoparticle releases its drug payload.
A Josephson junction with a weak link made of the quantum spin Hall insulator HgTe shows evidence of topological superconductivity in response to an a.c. excitation.
The phenomenon of circumferential faceting in multiwalled nanotubes of general chirality and identity is rationalized in terms of interwall registry patterns between adjacent layers of curved hexagonal lattices.
Quantum dots encapsulated inside DNA icosahedra that display a single endocytic ligand are used to track compartmental dynamics along endocytic pathways.
Solid-state nanopores can be used to directly observe individual knots in linear and circular DNA molecules of arbitrary length, and to determine the knot's size, position, and probability of occurrence as a function of DNA length.
Few-layered, vertically aligned MoS2 films can efficiently harvest visible light for photocatalytic water disinfection, allowing >99.999% bacteria to be rapidly inactivated.
Synthetic nanoparticles containing rapamycin — a common immunosuppressant drug — when co-administered with any free antigen can induce immune tolerance, offering a way to rescue novel drugs that have failed in the clinic due to antidrug antibodies.
A pore with a subnanometre diameter, created in a thin silicon nitride membrane, can be used to detect the primary structure of a denatured protein molecule.
Protein isoelectric points can now be obtained by measuring adhesion forces between the protein attached to an atomic force microscope probe and a reference surface with a known charge, offering a new way to characterize unknown and rare proteins.
The magnetic field-driven dynamics of nanosized magnetic vortex cores can be used to generate propagating short-wavelength spin waves in heterostructures with antiferromagnetically coupled layers.
Antiferromagnetic materials allow deterministic spin–orbit torque switching of perpendicular magnetization in ferromagnetic layers without external magnetic fields.
Large-scale electronic circuits can be assembled via the spatially controlled synthesis of heterostructures made of single-layer molybdenum disulfide contacting graphene.
DNA-PAINT, a super-resolution fluorescence microscopy technique that exploits programmable transient oligonucleotide hybridization, can be used to image densely packed triangular lattice patterns with molecular-level resolution and ångström-level precision.
Three-dimensional tissue-scaffold-mimicking nanoelectronics are used to map conduction pathways during cardiac tissue development, record action potential dynamics in disease and pharmacological models, and actively control action potential propagation.