Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Longitudinal shotgun metagenomics reveal changes in the gut microbial ecology upon carbapenemase-producing Enterobacteriaceae colonization and decolonization of adult subjects.
Viral genomes that infected two Asgard archaeal phyla recovered from deep-sea hydrothermal sediment metagenomes reveal that these viruses have characteristics of prokaryotic and eukaryotic viruses.
Algal production of dimethyl sulfide plays a role in attracting predators and enhancing predation by zooplankton, thus mediating predator–prey relationships in the ocean.
Structural analysis of two human monoclonal antibodies that conform the antibody cocktail AZD7442, in complex with the RBD of SARS-CoV-2, reveal strong neutralization of SARS-CoV-2 variants of concern.
Single-molecule live-cell imaging of LexA in Escherichia coli shows continuous self-cleavage of this SOS repressor across the bacterial population, even during unperturbed growth. This results in substantial differences in LexA abundance across individuals, leading to spontaneous SOS induction in some cells and enhancing bacterial survival in anticipation of stress.
A piggyBac transposon mutagenesis screen identifies the long non-coding RNA, DINOR, in the human fungal pathogen Candida auris. DINOR is a virulence factor and regulates fungal stress responses and filamentation.
Salmonella mutants with reduced ability to colonize the mouse gut and cause disease are selected for by vaccine-induced intestinal antibody responses in mice.
The in situ cryo-electron microscopy structure of the intact Salmonella flagellar basal body—including the inner membrane rotor, drive shaft and outer membrane bushing complex—elucidates the mechanisms of assembly of this complex macromolecular structure that enables bacterial motility.
A combination of genomics analyses and cultivation experiments from activated sludge leads to the identification of ‘Candidatus Mycosynbacter amalyticus’, an ultrasmall epiparasitic bacterium that can lyse other bacteria such as Gordonia amarae, a filamentous actinomycete commonly associated with foams in wastewater treatment plants.
Akkermansia muciniphila produces P9, a small protein that interacts with intercellular adhesion molecule 2 to increase thermogenesis and glucagon-like peptide-1 secretion in mice.
Salivary mucin-derived glycans downregulate genes of quorum-sensing systems associated with genetic competence, thereby suppressing the transformation of Streptococcus mutans.
Live-cell single-molecule imaging of different Bacillus subtilis divisome proteins that interact with FtsZ (such as FtsA, EzrA, SepF and ZapA) reveals different subcomplexes with distinct motility: stationary FtsZ-binding proteins that bind transiently to treadmilling FtsZ filaments, and moving complexes containing cell wall synthases.
The architecture and molecular composition of the rhoptry secretion system in Apicomplexa evolved from an Alveolata-specific fusion machinery ancestry.
The spatial integration of transcription and mRNA splicing in a dedicated sub-nuclear compartment underpins monogenic antigen expression in trypanosomes.
An analysis of gut microbiomes of patients with non-small-cell lung cancer reveals an association between Bifidobacterium bifidum abundance and response to cancer therapy. In murine models of syngeneic tumours, administration of commercial B. bifidum strains synergizes with immune checkpoint blockade to reduce tumour burden, but the therapeutic potential of B. bifidum is affected by strain-level variation.
Treatment of SARS-CoV-2-infected ferrets with a nucleoside analogue (MK-4482/EIDD-2801) reduced the viral load in the upper respiratory tract and suppressed the spread of the virus to untreated ferrets. Therapeutic administration of MK-4482/EIDD-2801 may have the potential to break SARS-CoV-2 transmission chains.
COVID-19-convalescent individuals maintain a strong neutralizing antibody response to SARS-CoV-2 that has cross-reactivity to SARS-CoV and MERS-CoV. Neutralizing antibody titres depend on the severity of the disease and are positively correlated with the frequency of CXCR3+ T follicular helper cells and lymphocyte counts.
In this study, the authors use a transcriptional regulator-induced phenotype screen coupled with network analysis to characterize adaptations of Mycobacterium tuberculosis to the first-line anti-tuberculosis drug isoniazid. They identify the transcriptional factor mce3R and the CtpD effector to have a role in Mycobacterium susceptibility to isoniazid.