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The development of mobile CRISPR interference (CRISPRi), a modular dCas9-based system that facilitates blocking of gene expression and is easily transferred via conjugation, enables genetic investigations in non-model bacteria.
The non-structural protein NSs of the severe fever with thrombocytopenia syndrome virus interacts with ABIN2 and promotes formation and signalling of the TPL2–ABIN2–p105 kinase complex to induce expression of the immune-suppressive cytokine IL-10 and enhance viral pathogenesis.